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. 2020 Aug;32(4):415–445. doi: 10.21147/j.issn.1000-9604.2020.04.01

5. Histological grade criteria of colorectal cancer (based on version WHO 2010).

Criterion Differentiation category Numerical grade* Descriptive grade
*, undifferentiated carcinoma (grade 4) is reserved for carcinomas with no gland formation, mucin production, neuroendocrine, squamous or sarcomatoid differentiation; WHO, World Health Organization; MSI-H, high-level microsatellite instability.
>95% with gland formation Well differentiated 1 Low level
50%−95% with gland formation Moderately differentiated 2 Low level
0−49% with gland formation Poorly differentiated 3 High level
MSI-H Variable Variable Low level