TABLE 3: Rational use of Thalidomide along with Clofazimine with reference to individual countries.

S.no	Reference	Country	Sample	Treatment	Clofazamine	Rationale-(Thalidomide
			size		Y=1 N=0	clofazamine) Interpretation
1	Fogagnolo et al 16	Brazil	2	Thalidomide 300mg/day, Prednisolone 80mg/day	0	No-Not always mandatory
2	Rahul nagar 17	India	3	I- Prednisolone 40 mg/day	1	Yes
				clofazimine 300 mgs/day
				thalidomide was tapered below 100 mgs/day.
				II- Prednisolone 40 mgs/day,clofazimine 100 mgs three times a day prednisolone in higher doses of 60 mgs/day. Two successive thalidomide courses were also found	1
				III- Prednisolone 40 mgs/day,clofazimine 100 mgs three times a day prednisolone in higher doses of 60 mgs/day. Two successive thalidomide courses were also found	1
3	Rattan et al 18	India	4	Thalidomide 100mg/thrice a day + MDT - MB	0	No
				Thalidomide 100mg/thrice a day + MDT - MB Thalidomide 100mg/thrice a day + MDT - MB
				Thalidomide 100mg/thrice a day + MDT - MB
4	Mahajan et al 21	India	1	Treatment restarted with prednisone (60 mg/day), clofazimine (100 mg three times/day), rifampicin (600 mg once a month), thalidomide (100 mg three times/day)	1	Yes
5	Jitendra ssv et al 22	India	1	Prednisolone 1 mg/kg/day	1	Yes
				Clofazimine 300 mg/day for six months and 100 mg/day for another six months
				Thalidomide 200 mg/day (STOPPED)
6	T . Narang et al 23	India	1	Started rationale dose but patient not tolerated (apremilast)	1	Yes
7	Barman et al 24	India	1	MDT, Thalidomide - 100mg, T. Prednisolone.	0	No
8	Richards 25	Pt from Micronesia- treated at Dallas, Texas	1	MDT, Prednisolone 60mg/day, Thalidomide - 100mg	0	No, Not always mandatory
9	Rodriguez 26	Colombia	1	MDT, Thalidomide 300mg/day, Prednisolone 50mg/day	0	No, Not always mandatory
10	Verma et al 27	India	1	MDT, Prednisolone 40mg/day, Thalidomide 100mg TDS, Azathiprine 50mg/twice daily.	0	No
11	Verma et al 27	India	1	MDT,Prednisolone 1mg/kg/day, Thallidomide 100mg QID for 4 months	0	No
12	Yogeesh HR et al 28	India	1	MDT, Prednisolone 30mg, Thalidomide 100mg TDS,	0	No
13	Faber et al 29	Netherlands	1	MDT, Steroids, Thalidomide 300mg, Pentoxiphylline 400mg, Finally, Infliximab 5mg/kg.	0	No, Not always mandatory
14	Hebe Petiti-Martin et al 30	Spain	1	MDT, Prednisolone, Thalidomide - 150mg/day [stopped], Enoxeparin, Acenocoumoral	0	No, Not always mandatory
15	Vetrichevel et al 31	India	1	MDT, Corticosteroids, Thalidomide 300mg/day then stopped, LMWheparin, Warfarin for 6 months.	0	No
16	Sundeep chowdary et al 32	India	1	Prednisolone (40-80 mg)	1	No
				Etanercept (50 mg / week) subcutaneously.
				Clofazimine (300 mg daily),
				Thalidomide (starting dose: 300 mg daily),
				Minocycline (100 mg daily),
				Clarithromycin (1 g daily),
				Ofloxacin (400 mg daily),
				Pentoxifylline (400 mg three times daily),
				Azathioprine (150 mg daily; later increased to 300 mg)
17	Julia Rocha Silva Santos et al 33	Brazi	1	Thalidomide (100- 300 mg/day)	0	No, Not always mandatory
		l		prednisone at (20 - 40mg/day)
				50mg of etanercept SC.
				Thalidomide was interrupted
				Prednisone was continued at a dose of 10mg/day
18	Gulanikar et al 34	India	1	Prednisolone 30mg . Thalidomide 100mg QID	0	No
19	Yamaghuchi et al 35	Japan	1	PSL 15-55 mg⁄ day,Thalidomide 100-300 mg⁄ day	0	No, Not always mandatory
20	Sharma et al 36	India	1	MDT	0	No
				Prednisolone 60 mg/d,
				Ibuprofen 400 mg t.i.d.
				colchicine 0.5 mg b.i.d.
				thalidomide 100mg bd and stopped
Rationale with respect to use of thalidomide in planned dose:
21	Satyendra Kumar Singh et al 37			Plan for Thalidomide in desired rationale dose
22	Prasan Kumar Panda et al 38			Plan for Thalidomide in desired rationale dose