Table 2.
Positive Laboratory Tests for Histoplasmosis Among Patients Reported From 9 States, 2018–2019
| Type of Test | Number of Patients (%), n = 293 |
|---|---|
| Antibody serology | |
| Complement fixation | 159 (54.3) |
| Median highest complement fixation titer (range), n = 152 | 1:64 (1:8–1:2048) |
| Complement fixation only | 51 (17.4) |
| Immunodiffusion H band | 48 (16.4) |
| Immunodiffusion H band only | 2 (0.7) |
| Immunodiffusion M band | 130 (44.4) |
| Immunodiffusion M band only | 24 (8.2) |
| Immunodiffusion H or M band | 136 (46.4) |
| Immunodiffusion H or M band only | 29 (9.9) |
| Antigen testing | |
| Enzyme immunoassay | 103 (35.2) |
| Median highest value (range), n = 75, ng/mL | 4.03 (0.50–26.20) |
| Enzyme immunoassay only | 36 (12.3) |
| Other diagnostic methods | |
| Culture | 67 (22.9) |
| Culture only | 19 (6.5) |
| Molecular evidence | 12 (4.1) |
| Histopathology | 21 (7.2) |
| Histopathology only | 1 (0.3) |
| Cytopathology/smear | 14 (4.8) |
| Cytopathology/smear only | 1 (0.3) |
| Type of Specimen | Number of Specimens (%) |
| Culture, n = 72 | |
| Bronchial specimen | 23 |
| Blood | 12 |
| Lymph node | 10 |
| Bone marrow | 9 |
| Sputum | 5 |
| Lung tissue | 3 |
| Other | 11 |
| Histopathology, n = 21 | |
| Lung tissue | 11 |
| Bone marrow | 3 |
| Lymph node | 3 |
| Bronchial specimen | 1 |
| Other | 3 |