Fig 2. Manganese Enhanced MR Imaging (MEMRI) of orthotopic human prostate cancer xenografts and CaSR/TRPV6 receptors levels.
Tumour diameter 10 mm. On T2-weighted MR image a high signal intensity multilobulated prostatic tumour is detected (red arrow). BC. On T1-weighted gradient echo MR images (T1 WI) recorded before and 90 minutes after Mn2+ administration, no changes in tumour signal enhancement was appreciated (red arrows). DE. Immunohistochemistry (IHC) of CaSR and TRPV6: both receptors were not detected in tumour cells (score 0) showing a negative staining. Scale bar = 100μ. F. Tumour diameter 6 mm. On T2-weighted image a high signal intensity extra-capsular prostatic tumour is detected (red arrow). GH. On T1-weighted gradient echo images (T1 WI) recorded before and 90 minutes after Mn2+ administration, no changes in tumour signal enhancement was appreciated (red arrows). IL. Immunohistochemistry (IHC) of CaSR and TRPV6: both receptors displayed a very low positive staining in tumour cells (score 1). Scale bar = 100μ.