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. 2020 Sep 15;15(9):e0224414. doi: 10.1371/journal.pone.0224414

Table 1. SNR and SE% (calculated as [(SNR-SNR0)/ SNR0]×100) for all tumour lesions respectively, of xenotransplant and pseudometastatic tumour animal model, before and 90 minutes after manganese administration and CaSR or TRPV6 expression levels evaluated by immunohistochemistry.

Xenotransplant lesions Before SNR After Mn2+ SNR SE % CaSR score TRPV6 Score
Orthotopic PC3 7,61 7,64 +0.4 0 0
Orthotopic PC3 4,90 5,27 +7.5 1 1
Orthotopic MDA-MB-231 5,99 5,87 -2.0 0 0
Orthotopic MDA-MB-231 6,15 11,75 +91 4 4
Osseous MDA-MB-231 10,11 9,35 -7.5 0 0
Pseudo-metastatic lesions (PC3) Before SNR0 After Mn2+ SNR SE % CaSR score TRPV6 score
Liver nodule 11,28 10,98 -2.6 1 4
Liver nodule 14,52 13,70 -5.6 1 4
Mediastinal nodule 11,13 14,85 +33 3 2
Mediastinal nodule 11,48 13,41 +17 2 2
Diaphragmatic nodule 8,97 13,15 +47 3 4
Peritoneal nodule 11,82 11,77 -0.4 1 1
Peritoneal nodule 13,76 13,64 -0.9 1 1