Table 1. SNR and SE% (calculated as [(SNR-SNR0)/ SNR0]×100) for all tumour lesions respectively, of xenotransplant and pseudometastatic tumour animal model, before and 90 minutes after manganese administration and CaSR or TRPV6 expression levels evaluated by immunohistochemistry.
Xenotransplant lesions | Before SNR | After Mn2+ SNR | SE % | CaSR score | TRPV6 Score |
Orthotopic PC3 | 7,61 | 7,64 | +0.4 | 0 | 0 |
Orthotopic PC3 | 4,90 | 5,27 | +7.5 | 1 | 1 |
Orthotopic MDA-MB-231 | 5,99 | 5,87 | -2.0 | 0 | 0 |
Orthotopic MDA-MB-231 | 6,15 | 11,75 | +91 | 4 | 4 |
Osseous MDA-MB-231 | 10,11 | 9,35 | -7.5 | 0 | 0 |
Pseudo-metastatic lesions (PC3) | Before SNR0 | After Mn2+ SNR | SE % | CaSR score | TRPV6 score |
Liver nodule | 11,28 | 10,98 | -2.6 | 1 | 4 |
Liver nodule | 14,52 | 13,70 | -5.6 | 1 | 4 |
Mediastinal nodule | 11,13 | 14,85 | +33 | 3 | 2 |
Mediastinal nodule | 11,48 | 13,41 | +17 | 2 | 2 |
Diaphragmatic nodule | 8,97 | 13,15 | +47 | 3 | 4 |
Peritoneal nodule | 11,82 | 11,77 | -0.4 | 1 | 1 |
Peritoneal nodule | 13,76 | 13,64 | -0.9 | 1 | 1 |