TABLE 1.

Diagnostic requirements for Brooke-Spiegler Syndrome

DIAGNOSTIC CRITERIA
Early stage of onset for skin neoplasms
Family history of neoplasms with autosomal dominance inheritance pattern
Histopathologic findings on biopsy of cylindromas, spiradenomas, or trichoepitheliomas
Increased association with tumors in parotid or salivary glands
Genetic testing confirming mutation in CYLD gene