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SARS-CoV-2 D614G S Protein Variant Binds ACE2 Weaker than the Ancestral Protein
(A–D) SPR measurement of D614-ACE2 binding ([A] and [C]) and D614G-ACE2 binding ([B] and [D]) at 25°C ([A] and [B]) or 37°C ([C] and [D]).
(E) Summary of kinetic parameters measured in (A)–(D). D614G binds ACE2 5-fold weaker than D614 at both temperatures tested.
