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. 2020 Sep 15;183(3):739–751.e8. doi: 10.1016/j.cell.2020.09.032

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D614G Populates More Open Conformations Than Does the Ancestral S Protein

(A) Cryo-EM density maps of the two conformations of D614G protomer. The first is a closed conformation with a buried RBD. The second is an open conformation with the RBD standing up.

(B) Atomic models for the closed (left) and open (right) conformations for the two D614G protomers shown in (A).

(C) Comparison of the two D614G protomer S1 subunit conformations with the corresponding conformations of the D614 protomer S1 subunit.

(D) The D614G S protein trimer adopts four conformations. In addition to the all-closed and one open conformation detected with the D614 S protein trimer, the D614G S protein trimer adopts two-open and three-open conformations.