Table 3.
In-Hospital Mortality and SARS-CoV-2 Admission Viral Load, Stratified by RT-PCR Assay
| cobas SARS-CoV-2 Assaya (%) | Xpert Xpress SARS-CoV-2 Assayb (%) | Combined Data from Both Assays (%) | |
|---|---|---|---|
| All Patients | |||
| High viral load (n = 941) | 37.5c | 40.9c | 38.8c |
| Medium viral load (n = 825) | 23.5 | 25.4 | 24.1 |
| Low viral load (n = 1,248) | 12.4 | 18.3 | 15.3 |
| Patients with Cancer | |||
| High viral load (n = 42) | 44.4 | 46.7 | 45.2d |
| Medium viral load (n = 25) | 35.3 | 12.5 | 28.0 |
| Low viral load (n = 33) | 20.0 | 8.7 | 12.1 |
Variables are expressed as in-hospital mortality percentage.
See Table S3 for this analysis using the cobas viral load cutoffs for both the cobas and Xpert Xpress assays.
a
High viral load, CT value < 25; medium viral load, CT value 25–30; low viral load, CT value > 30, using the ORF1ab gene target.
b
High viral load, CT value < 27; medium viral load, CT value 27–32; low viral load, CT value > 32, using the N2 gene target.
c
p value comparing mortality by viral load using a trend analysis was < 0.001.
d
p value comparing mortality by viral load using a trend analysis was 0.008.