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Serial changes in the median values of clinical parameters during the study. Note the significant worsening at the third liver biopsy (body mass index, second vs. third, p=0.018; waist circumference, second vs. third, p=0.018). Significant worsening of glucose metabolism was noted at the third liver biopsy (fasting plasma glucose, second vs. third, p=0.018; HbA1c, second vs. third, p=0.018).
