Table 1.
GATA3 expression and clinical characteristics of ccRCC
| Variables | Number (total n = 534) | GATA3 expression | P-value | |
|---|---|---|---|---|
| Low | High | |||
| Age (yr) | 0.3867 | |||
| ≤60 | 264 (49.44%) | 137 | 127 | |
| >60 | 270 (50.56%) | 130 | 140 | |
| Gender | 0.1029 | |||
| Male | 346 (64.79%) | 164 | 182 | |
| Female | 188 (35.21%) | 103 | 85 | |
| Tumor size | 0.0122* | |||
| T1 | 273 (51.12%) | 153 | 120 | |
| T2 | 69 (12.92%) | 35 | 34 | |
| T3 | 181 (33.90%) | 76 | 105 | |
| T4 | 11 (2.06%) | 3 | 8 | |
| Lymph nodes metastasis | 0.8696* | |||
| N0 | 240 (44.94%) | 117 | 123 | |
| N1 | 16 (3.00%) | 8 | 8 | |
| N/A | 278 (52.06%) | 142 | 136 | |
| Distant metastasis | 0.0112* | |||
| M0 | 424 (79.40%) | 212 | 212 | |
| M1 | 80 (14.98%) | 33 | 47 | |
| N/A | 30 (5.62%) | 22 | 8 | |
| Stage | 0.0204* | |||
| I | 269 (50.38%) | 151 | 118 | |
| II | 57 (10.67%) | 29 | 28 | |
| III | 123 (23.03%) | 50 | 73 | |
| IV | 85 (15.92%) | 37 | 48 | |
N/A not available
All data of the 534 patients with ccRCC were collected from TCGA database. Low GATA3 expression: lower than the median level of GATA3 expression of total patients. High GATA3 expression: higher than the median level of GATA3 expression of total patients. The patients’ number in each district was counted and analyzed by chi-square test. The statistical results suggest that the expression of GATA3 was significantly correlated with the tumor size, distant metastasis, and pathologic stage. However, there is no significant association between GATA3 expression and patients’ age, gender, and lymph nodes metastasis
*P < 0.05