Table 2.
Clinical trials investigating the use of CQ and HCQ to treat cancers
| Cancer | NCT number | Phase | Cancer | NCT number | Phase | Cancer | NCT number | Phase |
|---|---|---|---|---|---|---|---|---|
| CQ | ||||||||
| Brain metastasis | NCT01894633 | II | NCT00224978 | III | Myeloma | NCT01438177 | II | |
| NCT01727531 | N/A | NCT03243461 | III | Nonsmall cell lung | NCT02786589 | I/II | ||
| Breast | NCT02333890 | II | Glioma/cholangiocarcinoma/chondrosarcoma | NCT02496741 | I/II | Pancreatic | NCT01777477 | I |
| NCT01446016 | II | Hematological or solid tumor | NCT04333914 | II | Prolactinoma | NCT03400865 | N/A | |
| Ductal carcinoma | NCT01023477 | I/II | Malignant neoplasm | NCT02071537 | I | Small cell lung | NCT01575782 | I |
| Glioblastoma | NCT04397679 | I | NCT02366884 | II | NCT00969306 | I | ||
| NCT02378532 | I | Melanoma | NCT01469455 | I | ||||
| NCT02432417 | II | NCT03979651 | N/A | |||||
| HCQ | ||||||||
| Advanced | NCT01266057 | I | Lymphangioleiomyomatosis | NCT01687179 | I | Adenocarcinoma | NCT01978184 | II |
| Central nervous system tumors | NCT00486603 | I/II | Melanoma | NCT00962845 | I | NCT01128296 | I/II | |
| Breast | NCT04316169 | I | NCT02257424 | I/II | NCT03825289 | I | ||
| NCT02414776 | I | NCT03979651 | N/A | Prolactinoma | NCT03400865 | N/A | ||
| NCT03032406 | II | NCT03754179 | I/II | Prostate | NCT04011410 | II | ||
| NCT03774472 | I/II | NCT01897116 | I | NCT03513211 | I/II | |||
| NCT00765765 | I/II | Myelodysplastic Syndromes | NCT03929211 | I/II | NCT00726596 | II | ||
| NCT03400254 | I/II | Myeloma | NCT01689987 | I | NCT00786682 | II | ||
| NCT01292408 | II | NCT01396200 | I | NCT01828476 | II | |||
| Cholangiocarcinoma | NCT03377179 | II | NCT00568880 | I | NCT02421575 | I | ||
| Colorectal | NCT01006369 | II | NCT04163107 | I | Rectal/colon/adenocarcinoma | NCT01206530 | I/II | |
| NCT02316340 | II | Nephropathy | NCT02765594 | IVIII | Renal cell carcinoma | NCT01144169 | I | |
| NCT03215264 | I/II | Nonsmall cell lung cancer | NCT00809237 | I/II | NCT01550367 | I/II | ||
| Gastrointestinal | NCT04214418 | I/II | NCT01649947 | II | NCT01510119 | I/II | ||
| NCT04145297 | I | NCT01026844 | I | Sarcoma | NCT01842594 | II | ||
| Glioblastoma | NCT04201457 | I/II | NCT02470468 | I/II | Small cell lung | NCT02722369 | II | |
| NCT01602588 | II | NCT00977470 | II | Solid tumor | NCT01417403 | I | ||
| NCT03008148 | II/III | Osteosarcoma | NCT03598595 | I/II | NCT00714181 | I | ||
| Hematological malignancy | NCT04392128 | II | Ovarian cancer | NCT03081702 | I/II | NCT00909831 | I | |
| Hepatocellular | NCT03037437 | II | Pancreatic cancer | NCT04132505 | I | NCT02232243 | I | |
| NCT02013778 | I/II | NCT04386057 | II | NCT01023737 | I | |||
| Leukemia | NCT00771056 | II | NCT01506973 | I/II | NCT01634893 | I | ||
| NCT02631252 | I | NCT01273805 | II | NCT03015324 | I | |||
| NCT01227135 | II | NCT01494155 | II | NCT01480154 | I | |||
| Lung | NCT00728845 | I/II | NCT03344172 | II | NCT00813423 | I | ||