Table 3.

RDD results from Cohort B (treatment threshold of 4.5 h, after 2009).

Outcomes	Coefficients	Unadjusted		Adjusted		NIHSS Adjusted
Sharp RDD	Discontinuity, exp(b3)	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
Good discharge disposition	Before vs. after	0.95 (0.76–1.18)	0.627	0.92 (0.72–1.17)	0.504	0.86 (0.64–1.15)	0.300
Discharged home	Before vs. after	1.13 (0.93–1.37)	0.230	1.11 (0.90–1.38)	0.312	1.20 (0.92–1.55)	0.171
In-hospital mortality	Before vs. after	1.09 (0.70–1.71)	0.701	1.12 (0.71–1.77)	0.637	1.27 (0.71–2.28)	0.417
LOS ≤ 4 days	Before vs. after	1.21 (1.00–1.47)	0.056	1.20 (0.98–1.46)	0.081	1.33 (1.05–1.67)	0.017
Able to ambulate independently at discharge	Before vs. after	0.97 (0.80–1.19)	0.790	0.95 (0.77–1.17)	0.615	0.92 (0.72–1.18)	0.498
mRS 0–1 vs. 2–6	Before vs. after	1.26 (0.85–1.88)	0.254	1.29 (0.84–2.00)	0.250	1.42 (0.89–2.28)	0.144
Fuzzy RDD		Estimate	P-value	Estimate	P-value	Estimate	P-value
Stage 1	$b_1^{(1)}$
tPA	Before vs. after cutoff	0.977	<.0001	1.013	<.0001	1.043	<.0001
Stage 2	${\text{b}}_3^{(2)}$
Good discharge disposition	tPA Yes/No	−0.304	0.627	−0.517	0.408	−0.452	0.482
Discharged home	tPA Yes/No	0.653	0.230	0.482	0.353	1.292	0.028
In-hospital mortality	tPA Yes/No	0.484	0.701	0.071	0.951	0.652	0.579
LOS ≤ 4 days	tPA Yes/No	1.051	0.056	0.859	0.073	1.072	0.031
Able to ambulate independently at discharge	tPA Yes/No	−0.150	0.790	−0.543	0.304	−0.124	0.827
mRS 0–1 vs. 2–6	tPA Yes/No	1.276	0.254	0.265	0.791	1.037	0.291