Table 3.
AN(C)OVA results.
| HT | TPOonly | Subclinical hypothyroidism | Subclinical hyperthyroidism | Overt hypothyroidism | Overt hyperthyroidism | |
|---|---|---|---|---|---|---|
| KINDL | −0.69 [−3.00; 1.61] p = 0.555 |
2.50 [0.04; 4.95] p = 0.046 |
−0.32 [−1.82; 1.20] p = 0.999 |
−0.13 [−1.80; 1.53] p = 0.999 |
4.27 [−1.70; 10.24] p = 0.371 |
1.76 [−3.38; 6.90] p = −984 |
| SDQ | 0.38 [−0.75; 1.52] p = 0.507 |
−0.86 [−2.07; 0.36] p = 0.169 |
0.19 [−0.35; 0.71] p = 0.484 |
−0.65 [−1.22; −0.07] p = 0.028, d = 0.14 |
−2.40 [−4.45; −0.35] p = 0.022, d = 0.52 |
0.29 [−2.05; −1.48] p = 0.751 |
| z–TSH |
−1.37 [−1.57; −1.16] p < 0.001, d = 1.17 |
−0.43 [−0.65; −0.2] p < 0.001, d = 0.51 |
−2.44 [−2.54; −2.35] d = 3.49 |
2.56 [2.46; 2.67] d = 3.33 |
−4.25 [−4.62; −3.89] d = 1.64 |
3.67 [3.35; 3.99] d = 2.08 |
| z-fT4 | 0.00 [−0.20; 0.21] p = 0.967 |
0.09 [−0.13; 0.31] p = 0.443 |
[−0.09; 0.10] p = 0.917 |
−0.13 [−0.23; −0.02] p = 0.016, d = 0.15 |
3.39 [3.01; 3.77] p < 0.001, d = 1.71 |
−3.26 [−3.58; −2.93] p < 0.001, d = 2.48 |
| z–fT3 | 0.08 [−0.16; 0.31] p = 0.527 |
−0.24 [−0.50; 0.01] p = 0.055 |
−0.30 [−0.41; −0.18] p < 0.001, d = 0.29 |
−0.33 [−0.45; −0.20] p < 0.001, d = 0.24 |
0.95 [0.50; 1.40] p < 0.001, d = 0.75 |
−2.16 [−2.54; −1.78] p < 0.001, d = 0.99 |
| TPO-AB |
−390.81 [−453.43; −328.18] p < 0.001, d = 1.45 |
−200.83 [−266.54; −135.11] p < 0.001, d = 1.51 |
– | – | – | – |
| Urinary iodine excretion | −4.03 [−24.54; 16.48] p = 0.700 |
−1.41 [−22.89; 20.07] p = 0.898 |
−16.26 [−25.46; −7.06] p < 0.001, d = 0.19 |
−19.55 [−29.78; −9.33] p < 0.001, d = 0.24 |
−12.53 [−52.41; 27.34] p = 0.538 |
−17.94 [−49.49; 13.61] p = 0.265 |
| z-thyroid volume* |
−2481.12 [−2968.43; −1993.82] p < 0.001, d = 1.26 |
−1535.63 [−2076.89; −994.16] p < 0.001, d = 0.84 |
452.59 [192.10; 751.31] p = 0.001, d = 0.20 |
−275.67 [−571.04; 9.71] p = 0.058 |
278.28 [−729.41; 1285.97] p = 0.588 |
−1227.90 [−2083.37; −372.44] p = 0.005, d = 0.62 |
Significant contrasts are marked in bold, d refers to Cohen's effect size measure comparing means. Please note that differences in means may not correspond to results presented in Table 1B in case of ANCOVA testing and correction of means for covariates.
*
Results refer to differences in ranks but not z-standardized thyroid volume. Mean differences and the 95% confidence intervals in brackets between the respective group as outlined in each column and healthy controls FDR-corrected for multiple testing at q < 0.05.