. 2020 Sep 2;11:454. doi: 10.3389/fendo.2020.00454

Table 4.

Regression results.

	Controls		HT		TPO_only		Subclinical hypothyroidism		Subclinical hyperthyroidism		Overt hypothyroidism		Overt hyperthyroidism
	KINDL	SDQ	KINDL	SDQ	KINDL	SDQ	KINDL	SDQ	KINDL	SDQ	KINDL	SDQ	KINDL	SDQ
z-TSH	0.030 [t_{(6, 264)} = 2.50] p = 0.013 (sr² = 0.001)	−0.025 [t_{(6, 211)} = −1.98] p = 0.047 (sr² = 0.001)	−0.040 [t₍₆₀₎ = −0.27] p = 0.787	−0.072 [t₍₆₀₎ = −0.51] p = 0.614	0.254 [t₍₄₉₎ = 1.86] p = 0.069	−0.222 [t₍₄₇₎ = −1.18]p = 0.122	0.010 [t₍₂₄₇₎ = 0.15] p = 0.878	0.027 [t₍₂₃₄₎ = 0.42] p = 0.677	0.150 [t₍₁₈₇₎ = 2.14] p = 0.034 (sr² = 0.02)	0.009 [t₍₁₈₀₎ = 0.12] p = 0.906	0.449 [t₍₁₃₎ = 0.70] p = 0.498	−0.755 [t₍₁₃₎ = −1.37] p = 0.195	−0.315 [t₍₁₉₎ = −0.97] p = 0.344	0.105 [t₍₁₉₎ = 0.30] p = 0.770
z-fT4	−0.005 [t_{(6, 264)} = −0.42] p = 0.673	−0.011 [t_{(6, 211)} = −0.86] p = 0.390	−0.158 [t₍₆₀₎ = −1.12] p = 0.268	0.231 [t₍₆₀₎ = 1.67] p = 0.101	−0.01 [t₍₄₉₎ = −0.06] p = 0.949	0.241 [t₍₄₇₎ = 1.63] p = 0.110	0.045 [t₍₂₄₇₎ = 0.70] p = 0.486	−0.082 [t₍₂₃₄₎ = −1–24] p = 0.215	−0.009 [t₍₁₈₇₎ = −0.13] p = 0.901	−0.070 [t₍₁₈₀₎ = −0.95] p = 0.343	−0.24 [t₍₁₃₎ = −0.34] p = 0.740	0.321 [t₍₁₃₎ = 0.53] p = 0.605	−0.145 [t₍₁₉₎ = −0.47] p = 0.646	0.193 [t₍₁₉₎ = 0.55] p = 0.591
z-fT3	0.025 [t_{(6, 264)} = 2.04] p = 0.024 (sr² < 0.001)	−0.012 [t_{(6, 211)} = −0.98] p = 0.329	0.031 [t₍₆₀₎ = 0.24] p = 0.811	0.170 [t₍₆₀₎ = 1.32] p = 0.191	0.183 [t₍₄₉₎ = 1.25] p = 0.216	−0.159 [t₍₄₉₇₎ = −1.05] p = 0.298	0.056 [t₍₂₄₇₎ = 0.87] p = 0.387	0.074 [t₍₂₃₄₎ = 1.12] p = 0.266	−0.051 [t₍₁₈₇₎ = −0.69] p = 0.490	0.119 [t₍₁₈₀₎ = 1.52] p = 0.130	0.354 [t₍₁₃₎ = 1.05] p = 0.314	−0.686 [t₍₁₃₎ = −2.37] p = 0.034 (sr² = 0.02)	−0.206 [t₍₁₉₎ = −0.56] p = 0.585	0.039 [t₍₁₉₎ = 0.10] p = 0.925
TPO-AB	^#	^#	−0.096 [t₍₆₅₎ = −0.72] p = 0.472	0.023 [t₍₆₀₎ = 0.175] p = 0.861	−0.007 [t₍₄₉₎ = −0.05] p = 0.959	−0.043 [t₍₄₇₎ = −0.30] p = 0.765	^#	^#	^#	^#	^#	^#	^#	^#
Urine iodine	0.020 [t_{(6, 264)} = 1.66] p = 0.097	<0.001 [t_{(6, 211)} = 0.12] p = 0.991	^#	^#	^#	^#	0.024 [t₍₂₄₇₎ = 0.39] p = 0.692	−0.060 [t₍₂₃₄₎ = −0.94] p = 0.348	0.044 [t₍₁₈₇₎ = 0.62] p = 0.537	−0.030 [t₍₁₈₀₎ = −0.41] p = 0.685	^#	^#	^#	^#
z-thyroid volume	−0.010 [t_{(6, 264)} = −0.93] p = 0.408	−0.006 [t_{(6, 211)} = −0.47] p = 0.635	−0.123 [t₍₆₅₎ = −0.88] p = 0.385	−0.095 [t₍₆₀₎ = −0.69] p = 0.496	−0.166 [t₍₄₉₎ = −1.18] p = 0.244	0.049 [t₍₄₇₎ = 0.33] p = 0.740	−0.073 [t₍₂₄₇₎ = −1.20] p = 0.230	0.068 [t₍₂₃₄₎ = 1.08] p = 0.281	−0.070 [t₍₁₈₇₎ = −1.00] p = 0.317	0.096 [t₍₁₈₀₎ = 1.32] p = 0.187	0.363 [t₍₁₃₎ = 1.62] p = 0.130	−0.027 [t₍₁₃₎ = −0.14] p = 0.892	−0.180 [t₍₁₉₎ = −0.70] p = 0.494	0.137 [t₍₁₉₎ = 0.57] p = 0.577
R² $_{Thyroid}^{*}$	0.002 [F_{(4, 6264)} = 3.02] p = 0.01	0.001 [F_{(4, 6211)} = 1.27] p = 0.276	0.053 [F_{(5, 60)} = 0.67] p = 0.651	0.023 [F_{(5, 60)} = 1.14] p = 0.348	0.131 [F_{(5, 49)} = 1.47] p = 0.215	0.131 [F_{(5, 47)} = 1.41] p = 0.237	0.013 [F_{(5, 247)} = 0.68] p = 0.639	0.017 [F_{(5, 234)} = 0.89] p = 0.491	0.031 [F_{(5, 187)} = 1.313] p = 0.260	0.019 [F_{(5, 184)} = 0.78] p = 0.568	0.374 [F_{(4, 13)} = 1.94] p = 0.164	0.541 [F_{(4, 13)} = 3.83] p = 0.029	0.057 [F_{(4, 19)} = 0.29] p = 0.882	0.046 [F_{(4, 19)} = 0.30] p = 0.919

Significant findings FDR-corrected for multiple testing at q <0.05 are marked in bold, sr² is the squared semipartial correlation.

Indicates regressors not tested in the respective case for reasons outlined in the results section.

Indicates the proportion of variance in KINDL and SDQ scores accounted for by all the above thyroid parameters. Standardized regression coefficients (β) from multiple regression separately for participants with thyroid autoimmunity and thyroid dysfunction with the dependent variable KINDL-R score and SDQ total difficulties score.