Table 3.
Clinical findings 1 and 2 years after Roux-en-Y gastric bypass in subjects with normal glucose, prediabetes and type 2 diabetes at baseline. Data are presented as mean ± SEM.
| Pre-operation | 1 year post RYGB | 2 years post RYGB | P-value | |
|---|---|---|---|---|
| Weight (kg) | ||||
| NG | 113.6 ± 3.0 | 74.6 ± 2.3 | 76.8 ± 2.6 | < 0.001 |
| PreDM | 123.0 ± 4.1 | 82.7 ± 2.6 | 80.2 ± 2.7 | < 0.001 |
| T2DM | 118.0 ± 3.8 | 82.2 ± 2.4 | 83.6 ± 3.0 | < 0.001 |
| Waist (cm) | ||||
| NG | 118.9 ± 2.4 | 82.6 ± 18 | NA | < 0.001 |
| PreDM | 129.0 ± 2.7 | 92.1 ± 2.1 | NA | < 0.001 |
| T2DM | 128.7 ± 1.9 | 94.0 ± 2.1 | NA | < 0.001 |
| BMI (kg/m2) | ||||
| NG | 41.4 ± 0.9 | 26.5 ± 0.8 | 27.4 ± 0.9 | < 0.001 |
| PreDM | 43.0 ± 1.2 | 28.7 ± 0.7 | 28.1 ± 0.7 | < 0.001 |
| T2DM | 41.2 ± 0.8 | 28.8 ± 0.7 | 29.2 ± 0.9 | < 0.001 |
| fP-Glucose (mmol/L) | ||||
| NG | 5.2 ± 0.04 | 4.8 ± 0.1 | 4.7 ± 0.1 | < 0.001 |
| PreDM | 5.8 ± 0.1 | 5.0 ± 0.1 | 5.0 ± 0.1 | < 0.001 |
| T2DM | 8.6 ± 0.4 | 5.5 ± 0.2 | 5.4 ± 0.2 | < 0.001 |
| HbA1C (mmol/mol) | ||||
| NG | 35 ± 0.4 | 34.4 ± 0.7 | 35.3 ± 0.8 | 0.701 |
| PreDM | 40 ± 0.6 | 36 ± 0.5 | 37 ± 0.5 | < 0.001 |
| T2DM | 57 ± 3.2 | 39 ± 0.9 | 40 ± 1.0 | < 0.001 |
| Fasting P-Insulin (mU/L) | ||||
| NG (n = 15) | 9.2 ± 1.5 | 4.0 ± 0.4 | NA | < 0.001 |
| PreDM (n = 27) | 12.0 ± 1.2 | 5.2 ± 0.7 | NA | < 0.001 |
| T2DM (n = 20) | 13.7 ± 1.3 | 5.3 ± 0.7 | NA | < 0.001 |
| HOMA-IR | ||||
| NG (n = 14) | 2.2 ± 0.4 | 0.9 ± 0.09 | NA | < 0.001 |
| PreDM (n = 27) | 3.2 ± 0.3 | 1.1 ± 0.2 | NA | < 0.001 |
| T2DM (n = 20) | 5.3 ± 0.5 | 1.3 ± 0.2 | NA | < 0.001 |
| Triglycerides (mmol/L) | ||||
| NG | 1.5 ± 0.3 | 0.9 ± 0.1 | 0.9 ± 0.1 | < 0.001 |
| PreDM | 1.6 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 | < 0.001 |
| T2DM | 1.9 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 | < 0.001 |
| LDL cholesterol (mmol/L) | ||||
| NG | 3.2 ± 0.1 | 2.3 ± 0.1 | 2.5 ± 0.2 | < 0.001 |
| PreDM | 3.3 ± 0.2 | 2.4 ± 0.1 | 2.6 ± 0.1 | < 0.001 |
| T2DM | 2.9 ± 0.2 | 2.5 ± 0.1 | 2.8 ± 0.1 | 0.089 |
| HDL cholesterol (mmol/L) | ||||
| NG | 1.2 ± 0.1 | 1.6 ± 0.1 | 1.7 ± 0.1 | < 0.001 |
| PreDM | 1.1 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | < 0.001 |
| T2DM | 0.9 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | < 0.001 |
| Systolic BP (mmHg) | ||||
| NG | 138.5 ± 2.5 | 121.2 ± 2.1 | 118.6 ± 2.2 | < 0.001 |
| PreDM | 141.8 ± 2.5 | 126.1 ± 2.2 | 128.2 ± 2.8 | < 0.001 |
| T2DM | 150.9 ± 3.8 | 131.4 ± 3.0 | 135.5 ± 3.4 | 0.044 |
| Diastolic BP (mmHg) | ||||
| NG | 83.3 ± 1.3 | 78.6 ± 1.1 | 79.7 ± 1.7 | < 0.001 |
| PreDM | 83.3 ± 1.3 | 78.6 ± 1.1 | 79.7 ± 1.7 | 0.049 |
| T2DM | 85.9 ± 1.8 | 79.3 ± 1.4 | 81.3 ± 1.7 | 0.026 |
NG normal glucose levels, PreDM prediabetes, T2DM type 2 diabetes, RYGB Roux-en-Y gastric bypass, NA not available, HOMA-IR homeostatic model assessment of insulin resistance, BP blood pressure.