Table 2.
Univariate analysis on overall survival and disease-free survival of the prognostic factors in high-risk stage II patients.
| Variable | n | OS, % | HR (95%CI) | P-value | DFS, % | HR (95%CI) | P-value |
|---|---|---|---|---|---|---|---|
| Age | 0.034 | 0.057 | |||||
| ≤63 | 90 | 80.0 | 1 | 75.6 | 1 | ||
| >63 | 98 | 90.8 | 0.431 (0.194–0.960) | 86.7 | 0.520 (0.262–1032) | ||
| Lymph nodes sampling | 0.950 | 0.814 | |||||
| ≥12 | 152 | 85.5 | 1 | 80.9 | 1 | ||
| <12 | 36 | 86.1 | 1.032 (0.390–2.727) | 83.3 | 0.900 (0.373–2.169) | ||
| Histological grade | 0.690 | 0.433 | |||||
| Well differentiated | 7 | 71.4 | 1 | 71.4 | 1 | ||
| Moderately differentiated | 123 | 85.4 | 0.548 (0.127–2.375) | 78.9 | 0.782 (0.185–3.310) | ||
| Poorly differentiated | 55 | 87.3 | 0.464 (0.096–2.248) | 87.3 | 0.446 (0.092–2.156) | ||
| Mucinous | 3 | 100.0 | – | 100.0 | – | ||
| Vascular or perineural invasion | 0.920 | 0.420 | |||||
| Yes | 55 | 87.3 | 1 | 80.0 | 1 | ||
| No | 133 | 85.0 | 0.956 (0.402–2.276) | 82.0 | 0.745 (0.363–1.528) | ||
| pTstage | 0.053 | 0.024 | |||||
| pT3 | 125 | 90.4 | 1 | 87.2 | 1 | ||
| pT4 | 63 | 76.2 | 2.111 (0.974–4.576) | 79.8 | 2.111 (0.974–4.576) | ||
| Intestinal occlusion or perforation | 0.349 | 0.574 | |||||
| Yes | 37 | 81.1 | 1 | 78.4 | 1 | ||
| No | 151 | 86.8 | 0.665 (0.281–1.573) | 82.1 | 0.798 (0.362–1.757) | ||
| Mismatch repair status | 0.248 | 0.340 | |||||
| pMMR | 124 | 84.7 | 1 | 80.6 | 1 | ||
| dMMR | 64 | 87.5 | 0.611 (0.165–1.410) | 82.8 | 0.704 (0.342–1.447) | ||
| Adjuvant chemotherapy | 0.122 | 0.244 | |||||
| No | 81 | 81.5 | 1 | 77.8 | 1 | ||
| Yes | 107 | 88.8 | 0.552 (0.258–1.184) | 84.1 | 0.675 (0.347–1.313) | ||
| DNA ploidy | 0.053 | 0.006 | |||||
| Diploid | 88 | 90.9 | 1 | 89.8 | 1 | ||
| Non-diploid | 100 | 81.0 | 2.216 (0.969–5.068) | 74.0 | 2.770 (1.296–5.918) | ||
| Stroma | 0.345 | 0.118 | |||||
| Low stroma | 153 | 86.9 | 1 | 83.7 | 1 | ||
| High stroma | 35 | 80.0 | 1.510 (0.638–3.573) | 71.4 | 1.782 (0.855–3.711) | ||
| Nucleotyping | 0.001 | <0.001 | |||||
| Chromatin homogeneous | 152 | 89.5 | 1 | 86.2 | 1 | ||
| Chromatin heterogeneous | 36 | 69.4 | 3.518 (1.618–7.646) | 61.1 | 3.302 (1.671–6.526) | ||
| DNA ploidy and stroma | 0.135 | 0.011 | |||||
| Diploid and low stroma | 77 | 90.9 | 1 | 89.6 | 1 | ||
| Diploid and high stroma or non-diploid and low stroma | 87 | 83.9 | 1.802 (0.727–4.466) | 79.3 | 2.081 (0.905–4.788) | ||
| Non-diploid and high stroma | 24 | 75.0 | 2.926 (0.982–8.712) | 62.5 | 4.036 (1.556–10.472) | ||
| Nucleotyping and stroma | 0.033 | 0.003 | |||||
| Chromatin homogeneous and low-stroma | 130 | 90.0 | 1 | 86.9 | 1 | ||
| Chromatin homogeneous and high-stroma or Chromatin heterogeneous and low-stroma | 45 | 77.8 | 2.345 (1.028–5.349) | 73.3 | 2.148 (1.026–4.499) | ||
| Chromatin heterogeneous and high-stroma | 13 | 69.2 | 3.575 (1.159–11.033) | 53.8 | 4.161 (1.635–10.595) | ||
| DNA ploidy and nucleotyping | 0.002 | <0.001 | |||||
| Diploid and chromatin homogeneous | 87 | 90.8 | 1 | 89.7 | 1 | ||
| Diploid and chromatin heterogeneous or non-diploid and chromatin homogeneous | 66 | 87.9 | 1.330 (0.499–3.545) | 81.8 | 1.845 (0.777–4.382) | ||
| Non-diploid and chromatin heterogeneous | 35 | 68.6 | 4.140 (1.653–10.370) | 60.0 | 4.632 (1.995–10.752) |
pMMR mismatch repair proficient, dMMR mismatch repair deficient, OS overall survival, DFS disease-free survival.