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. 2020 Sep 15;11(9):761. doi: 10.1038/s41419-020-02981-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The volume of the tumor during the process of tumor growth at seven different time points was determined (n = 6). b The tumor diameters of the six groups were measured 31 days after cell inoculation (n = 6). (1) NS group, injected with normal saline intratumorally; (2) NC-anta group, injected with negative control for antagomir intratumorally; (3) miR-337-3p-anta group, injected with miR-337-3p antagomir intratumorally; (4) stress + NS group; being restrained and injected with normal saline intratumorally; (5) stress + NC-ago group; being restrained and injected with negative control for agomir intratumorally; (6) stress + miR-337-3p-ago group, being restrained and injected with miR-337-3p agomir. c The tumor weight of the six groups is shown in diagram (n = 6). d Representative lung images from the six groups are displayed 31 days after cell inoculation. e The number of metastatic nodules of lungs from tumor-bearing BALB/c mice in six groups were calculated (n = 6). Data are shown as the mean ± SD; *P < 0.05; **P < 0.01.