Table 2.

Details of Δ₁ and Δ₂, i.e. relative changes of T1, T1ρ, T2, and T2* at δ₁ versus δ₀ and at δ₂ versus δ₀ during the pre- and post-exposure measurement series, as a function of trypsin exposure, region-of-interest, and loading intensity.

	Pre exposure		Post exposure		p value
	Δ1pre	Δ2pre	Δ1post	Δ2post	Δ1pre vs. Δ1post	Δ2pre vs. Δ2post
T1
Low trypsin
Entire	− 3.7 ± 2.3	− 7.4 ± 3.2	− 3.4 ± 2.4	− 7.1 ± 2.6	1.000	1.000
SPA	− 6.0 ± 2.2	− 10.2 ± 3.3	− 5.0 ± 2.7	− 10.4 ± 3.8	1.000	1.000
SPA upper	− 8.6 ± 2.8	− 15.5 ± 4.6	− 8.0 ± 3.2	− 15.4 ± 4.1	0.922	0.922
SPA lower	− 2.6 ± 3.7	− 3.5 ± 4.2	− 0.9 ± 4.1	− 3.8 ± 5.1	0.584	0.880
PPA	− 0.6 ± 2.7	− 3.5 ± 3.3	− 1.0 ± 3.0	− 3.1 ± 3.0	1.000	1.000
PPA upper	− 0.9 ± 2.8	− 4.7 ± 3.6	− 1.8 ± 4	− 4.3 ± 3.8	0.566	0.568
PPA lower	0.2 ± 4.7	− 1.5 ± 5.0	0.4 ± 2.9	− 0.5 ± 6.2	1.000	1.000
High trypsin
Entire	− 5.0 ± 3.5	− 10.4 ± 4.2	− 6.4 ± 3.5	− 11.5 ± 2.4	0.720	0.720
SPA	− 6.3 ± 4.1	− 12.6 ± 5.0	− 9.0 ± 2.6	− 15.2 ± 2.7	0.106	0.092
SPA upper	− 9.6 ± 5.1	− 17.2 ± 6.5	− 15.1 ± 5.4	− 23.0 ± 5.8	0.002	0.003
SPA lower	− 2.0 ± 4.2	− 6.7 ± 4.6	− 0.8 ± 6.8	− 4.6 ± 4.1	0.706	0.494
PPA	− 2.7 ± 3.3	− 6.7 ± 4.0	− 2.4 ± 5.2	− 6.2 ± 3.6	1.000	1.000
PPA upper	− 4.0 ± 4.8	− 8.4 ± 5.6	− 4.8 ± 5.2	− 9.0 ± 5.1	1.000	1.000
PPA lower	− 1.7 ± 4.0	− 4.3 ± 2.6	2.4 ± 8.8	− 0.2 ± 6.1	0.172	0.152
Controls
Entire	− 4.3 ± 2.5	− 8.4 ± 2.1	− 4.2 ± 2.2	− 8.1 ± 3.1	1.000	1.000
SPA	− 4.9 ± 2.4	− 9.2 ± 2.3	− 5.5 ± 3.1	− 9.6 ± 3.2	0.650	0.745
SPA upper	− 7.7 ± 4.5	− 13.9 ± 4.1	− 8.8 ± 4.0	− 14.8 ± 3.3	0.594	0.594
SPA lower	− 2.1 ± 2.8	− 4.1 ± 3.6	− 1.7 ± 3.7	− 2.6 ± 5.0	0.908	0.908
PPA	− 2.8 ± 2.9	− 6.7 ± 4.4	− 2.1 ± 1.8	− 5.9 ± 4.0	0.768	0.768
PPA upper	− 3.9 ± 3.1	− 8.7 ± 5.0	− 3.5 ± 2.7	− 9.0 ± 5.1	1.000	1.000
PPA lower	− 0.9 ± 3.6	− 2.1 ± 4.7	0.2 ± 4.0	− 1.2 ± 5.3	1.000	1.000
T1ρ
Low trypsin
Entire	13.3 ± 3.6	15.5 ± 6.2	12.2 ± 4.5	12.0 ± 7.4	0.367	0.140
SPA	15.5 ± 4.5	16.9 ± 7.9	13.8 ± 6.0	13.2 ± 7.2	1.000	1.000
SPA upper	21.3 ± 6.4	20.9 ± 7.9	18.8 ± 5.9	16.7 ± 8.3	0.324	0.324
SPA lower	9.4 ± 8.1	12.8 ± 11.3	8.7 ± 11.8	10.3 ± 12.5	0.765	0.082
PPA	9.1 ± 4.1	12.6 ± 4.6	9.9 ± 6.0	11.3 ± 10.0	1.000	1.000
PPA upper	12.6 ± 6	15.8 ± 5.2	13.6 ± 9.4	14.3 ± 11.4	1.000	1.000
PPA lower	5.4 ± 5.7	9.1 ± 6.1	5.5 ± 10.1	7.9 ± 13.1	1.000	1.000
High trypsin
Entire	13.5 ± 8.2	15.4 ± 9.4	12.6 ± 10.2	17.1 ± 26.2	1.000	1.000
SPA	16.1 ± 9.2	17.6 ± 10.7	14.4 ± 12.1	20.2 ± 32.9	1.000	1.000
SPA upper	18.2 ± 9.5	17.3 ± 13.1	15.0 ± 13.5	17.1 ± 30.8	1.000	1.000
SPA lower	13.8 ± 9.8	18.4 ± 10.5	14.0 ± 13.4	24.6 ± 36.5	1.000	1.000
PPA	8.2 ± 8.4	11.4 ± 9.3	8.3 ± 9.3	10.7 ± 9.3	1.000	1.000
PPA upper	9.1 ± 8.7	11.6 ± 8.0	7.2 ± 9.8	7.4 ± 12.0	0.508	0.486
PPA lower	6.9 ± 9.7	11.1 ± 11.8	10.1 ± 11.8	15.8 ± 11.8	0.646	0.646
Controls
Entire	8.9 ± 4.6	9.3 ± 5.7	13.3 ± 6.1	15.9 ± 7.0	0.084	0.034
SPA	10.8 ± 4.4	11.5 ± 5.6	15.3 ± 5.4	17.8 ± 6.6	0.061	0.040
SPA upper	14.8 ± 6.3	13.4 ± 6.2	19.3 ± 8.5	20.8 ± 9.4	0.104	0.070
SPA lower	6.7 ± 9.3	9.6 ± 10.7	11.4 ± 11.2	14.9 ± 12.2	0.187	0.166
PPA	4.3 ± 6.6	4.2 ± 8.1	8.2 ± 7.7	11.4 ± 8.7	0.209	0.030
PPA upper	5.2 ± 7.5	5.3 ± 7.7	11.5 ± 7.8	12.9 ± 9.6	0.059	0.012
PPA lower	3.2 ± 10.3	2.8 ± 11.5	4.9 ± 9.1	9.7 ± 9.4	0.665	0.200
T2
Low trypsin
entire	5.5 ± 3.2	4.2 ± 5.6	2.4 ± 3.8	1.9 ± 7.2	0.064	0.237
SPA	5.0 ± 4.4	2.9 ± 7.7	1.4 ± 3.9	− 0.2 ± 7.6	0.244	0.667
SPA upper	5.1 ± 5.7	1.4 ± 7.5	0.0 ± 5.5	− 4.3 ± 8.8	0.020	0.076
SPA lower	4.9 ± 5.9	5.9 ± 12.2	3.6 ± 6.0	6.3 ± 8.7	1.000	1.000
PPA	6.2 ± 3.3	6.4 ± 4.9	4.1 ± 4.6	5.6 ± 9.1	0.244	0.667
PPA upper	8.0 ± 2.7	7.1 ± 5.1	4.9 ± 5.0	5.7 ± 9.3	0.042	0.466
PPA lower	4.2 ± 5.6	6.2 ± 6.1	2.1 ± 6.3	5.1 ± 10.8	0.842	0.842
High trypsin
Entire	1.1 ± 3.3	− 0.3 ± 5.1	− 1.5 ± 4.2	− 6.2 ± 6.4	0.210	0.026
SPA	− 0.2 ± 4.7	− 2.9 ± 7.4	− 3.0 ± 6.2	− 9.9 ± 9.0	0.235	0.008
SPA upper	− 0.5 ± 6.5	− 7.4 ± 9.9	− 4.9 ± 8.4	− 15.2 ± 11.8	0.188	0.014
SPA lower	0.2 ± 4.7	3.7 ± 7.1	0.2 ± 7.7	− 0.9 ± 10.8	0.998	0.126
PPA	3.5 ± 5.4	3.8 ± 5.1	0.9 ± 5.5	1.0 ± 6.8	0.468	0.468
PPA upper	4.7 ± 6.1	3.8 ± 7.0	1.3 ± 6.5	0.0 ± 7.8	0.328	0.328
PPA lower	1.7 ± 7.2	3.0 ± 6.1	0.2 ± 6.3	3.1 ± 7.4	1.000	1.000
Controls
Entire	0.2 ± 3.8	− 2.9 ± 4.7	− 1.1 ± 4.7	− 2.8 ± 4.7	0.986	0.997
SPA	− 0.5 ± 4.4	− 3.7 ± 5.2	− 2.1 ± 5.0	− 4.4 ± 4.5	0.892	0.892
SPA upper	0.8 ± 3.3	− 5.8 ± 4	− 1.4 ± 5.5	− 5.9 ± 4.9	0.366	0.961
SPA lower	− 1.6 ± 6.1	− 0.9 ± 8.1	− 3.2 ± 5.6	− 2.0 ± 8.9	1.000	1.000
PPA	2.4 ± 4.6	− 0.2 ± 5.7	1.2 ± 5.0	0.5 ± 7.2	1.000	1.000
PPA upper	2.9 ± 5.1	− 0.5 ± 5.2	3.6 ± 3.6	0.2 ± 7.9	1.000	1.000
PPA lower	0.5 ± 5.9	− 1.1 ± 6.4	0.3 ± 8.1	1.4 ± 8.5	0.926	0.470
T2*
Low trypsin
Entire	8.3 ± 6.8	7.0 ± 6.1	5.0 ± 3.9	3.2 ± 4.9	0.136	0.136
SPA	8.2 ± 7.7	6.1 ± 8.4	3.9 ± 4.3	1.5 ± 5.1	0.310	0.310
SPA upper	5.1 ± 8.7	2.5 ± 8.6	− 0.1 ± 7.1	− 2.6 ± 7.0	0.028	0.061
SPA lower	12.7 ± 11	11.9 ± 11.4	10.7 ± 9.5	8.8 ± 6.0	0.868	0.868
PPA	8.4 ± 6.2	8.7 ± 4.5	6.6 ± 4.3	6.3 ± 7.6	0.310	0.310
PPA upper	8.6 ± 6.4	7.7 ± 4.8	5.4 ± 7.4	4.9 ± 8.8	0.002	0.253
PPA lower	8.8 ± 6.6	11.2 ± 5.7	7.9 ± 7.4	8.0 ± 10.0	0.806	0.806
High trypsin
Entire	3.6 ± 4.3	1.2 ± 6.1	2.7 ± 6.3	− 8.2 ± 14.6	0.657	0.046
SPA	2.2 ± 5.4	− 1.5 ± 8.1	1.6 ± 8.8	− 11.6 ± 17.2	0.800	0.074
SPA upper	0.3 ± 7.4	− 6.8 ± 10.3	− 2.9 ± 11.5	− 16.3 ± 18.4	0.327	0.056
SPA lower	5.3 ± 6.4	7.4 ± 9.7	7.2 ± 8.2	− 4.1 ± 20.2	0.248	0.130
PPA	6.2 ± 5.3	6.2 ± 5.5	4.7 ± 6.3	− 0.8 ± 13.1	0.463	0.088
PPA upper	4.7 ± 6.8	4.5 ± 9.1	2.2 ± 9.6	− 1.3 ± 11.8	0.365	0.046
PPA lower	8.9 ± 8.7	8.3 ± 7.2	8.4 ± 7.7	1.0 ± 18.3	0.875	0.500
Controls
Entire	2.0 ± 5.3	− 0.5 ± 6.1	0.1 ± 5.2	− 2.3 ± 4.5	0.788	0.788
SPA	1.0 ± 5.8	− 1.3 ± 6.5	− 1.2 ± 5.6	− 3.9 ± 4.5	0.552	0.552
SPA upper	0.8 ± 5.5	− 3.3 ± 6.4	− 2.7 ± 5.6	− 7.2 ± 4.5	0.230	0.230
SPA lower	1.9 ± 7.2	1.1 ± 9.6	1.1 ± 6.8	0.8 ± 7.3	1.000	1.000
PPA	6.4 ± 10.6	3.0 ± 8.8	2.5 ± 4.6	0.9 ± 7.0	0.730	0.730
PPA upper	5.6 ± 10.2	0.8 ± 9.1	3.8 ± 5.3	0.2 ± 8.1	1.000	1.000
PPA lower	7.5 ± 20.3	6.2 ± 14.6	3.7 ± 8.4	3.2 ± 9.4	1.000	1.000

Pre- and post-exposure values of Δ₁ and Δ₂ were comparatively evaluated using paired Student's t-tests. Data are mean ± standard deviation [%]. Significant differences are indicated in bold type.