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. 2020 Sep 2;11:614. doi: 10.3389/fendo.2020.00614

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Copyright © 2020 Hjortebjerg, Espelund, Rasmussen, Folkersen, Steiniche, Georgsen, Oxvig and Frystyk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical staining of PAPP-A2. Expression of PAPP-A2 in lung cancer tissue was determined by immunohistochemical staining. Examples are shown for two patients with non-small cell lung cancer of adenocarcinoma subtype. PAPP-A2 staining was present in malignant cells in recognizable glandular patterns as well as areas densely infiltrated by macrophages. Staining was moderate (left) and weak (right) and occurred in a heterogeneous pattern. Scale bar = 100 μm. PAPP-A2, pregnancy-associated plasma protein-A2.