Table 2.
Specific clusters of myeloid cells highlighted in the text are summarized here.
| Outstanding clusters | Hypothesized role | Cell type | Tumor studied | Species | Reference |
|---|---|---|---|---|---|
| STAT3, B7H3, CSF1R, CCL3, SIGLEC1 | Additional myeloid recruitment | TAM | Breast cancer | Human | (43) |
| PPARG, NRP2 | T cell suppression | TAM | Breast cancer, lung cancer | Human, murine | (43, 106, 112) |
| PD-L1 | T cell suppression | TAM | Breast cancer | Human | (107) |
| CD38 | Tumor proliferation and migration | M-MDSC | Breast cancer | Human | (107) |
| TREM2, APOE, MARCO | Mature TAM markers; global immunosuppression; anti-apoptosis | TAM | Breast cancer, lung cancer | Human | (43, 112, 113) |
| IFITM1, SOCS3, TSPO | Global immunosuppression; ROS production and T cell suppression | MDSC | Breast cancer | Murine | (20) |
| LILRB2 | Global immunosuppression | Monocyte-early TAM/MDSC | Lung cancer, GBM | Human | (106, 114) |
| CCL2, CCL3, CCL8, IDO1, IL1RN, IL4I1, NFKBIA, VISTA, LILRB4 | Additional myeloid recruitment; global immunosuppression | Monocyte-early TAM | Lung cancer | Human | (113) |
| CXCL9, CXCL10, CXCL11, STAT3, CCR2, LILRB2, PDL1, IL4I1, IDO1 | Global immunosuppression; T cell recruitment & suppression; chemotherapy resistance | TAM | Lung cancer | Human | (115) |
| IL10, TGFB2 | Global immunosuppression; tumor progression | MDSC & infiltrating macrophage | GBM | Human, rat | (116–118) |
| TSPO | ROS production and T cell suppression | Infiltrating macrophage | GBM | Human | (116) |
| VEGFA, HIF1A | Tumor progression | Infiltrating macrophage | GBM | Human | (114) |
| PDL1, B7H3, CD86 | T cell suppression | Microglia | GBM | Human | (114) |
| CCL3, TGFB2 | Additional myeloid recruitment | MDSC | GBM | Human | (116) |
Several clusters overlapped between various malignancies.