Table 3.
Therapies used to reprogram tumor associated macrophages and MDSCs.
| Target | Therapy/Treatment | Clinical Trials | References |
|---|---|---|---|
| BTK/ PI3Kγ | Small molecule BTK inhibitor: Ibrutinib Small molecule PI3K inhibitor: IPI-549 |
NCT03379428 NCT02403271 NCT02321540 NCT02950038 NCT02403271 NCT03535350 NCT03961698 NCT03719326 |
(158) (159) |
| LILRB | Anti-LILRB2 antibody | N/A | (131) |
| C5a/C5aR | C5aR genetic deletion | N/A | (160) |
| Dectin-1 (CLEC7A)/Gal-9 | Anti-Gal-9 antibody | N/A | (161) |
| CSF-1/CSF-1R | Small molecule CSF-1R inhibitor: BLZ945 | NCT02829723 | (162) |
| IL-1β | Anti-IL-1β antibody |
NCT02900664 NCT03742349 NCT03447769 NCT03968419 NCT03631199 NCT03626545 NCT03064854 |
(163) |
| HIF1α/β | HIF1 genetic deletion | N/A NCT01036113 |
(164) |
| ANGPT2/TIE2 | Small molecule TIE2 inhibitor: Rebastinib Anti-ANGPT2 antibody: Nesvacumab |
NCT02824575 NCT03717415 NCT03601897 NCT01688960 |
(164) (165) |
| PERK (UPR) | Inhibitor of unfolded protein response: Tauroursodeoxycholic acid (TUDCA) | N/A | (166) |
| Glutamine Synthetase (GS) | Methionine Sulfoxamine | N/A | (167) |
| CPT1 (FAO enzyme)HADHA (FAO enzyme) | Small molecule CPT1 inhibitor: Etoximir/Perhexiline Small molecule HADHA inhibitor: Ranolazine |
N/A | (168) (169) (170) |
| FPP | Small molecule FPP inhibitor: Zoledronic Acid |
NCT02347163 NCT00295867 NCT00320710 NCT03664687 |
(171) (172) (173) |
| MARCO | Anti-MARCO antibody | N/A | (150) |
| IRF5IKKβ | Nanoparticle encapsulated mRNAs | N/A | (174) |
| DICER | DICER genetic deletion |
NCT01353300 NCT00565903 |
(175) |
| PD-1/PD-L1 | PD-1 genetic deletionAnti-PD-1 antibody |
NCT04173325 NCT03414684 NCT03925246 |
(108) (109) |