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. 2020 Sep 2;8:859. doi: 10.3389/fcell.2020.00859

FIGURE 2.

FIGURE 2

Phenotypes of muscle-specific Rpt3-knockout mice. (A) Timeline of doxycycline (DOX) treatment. (B) Comparison of body weights between Con and mKO mice before and after DOX treatment. Data represent the means ± SEM (t-test: n.s., not significant; n = 3–4 per group). (C) Comparison of tibialis anterior, gastrocnemius, and soleus muscle weights between Con and mKO mice after DOX treatment. Data represent the means ± SEM (t-test: n.s., not significant, ****p < 0.0001; n = 3–4 per group). (D) Comparison of tibialis anterior, gastrocnemius, and soleus muscle weight-to-body weight ratios between Con and mKO mice after DOX treatment. Data represent the means ± SEM (t-test: n.s., not significant, **p < 0.01, ***p < 0.001; n = 3–4 per group). (E) Comparison of grip strength between Con and mKO mice. Data represent the means ± SEM (t-test: **p < 0.01; n = 3–4 per group). Con indicates Rpt3f/f mice, and mKO indicates muscle-specific Rpt3-knockout mice (ACTA1-rtTA;tetO-Cre;Rpt3f/f).