Fig. 4.

Analysis of the phylogenetic distance among bacterial genera calculated by the Bray-Curtis method for the endometrium (a) and for the vagina (b) and for the paired each type of sample, pre- and post-COS (c, d). Color data points according to alpha diversity (Shannon index). Connecting lines join the paired samples. The Bray-Curtis distance index is calculated with the formula 1 − (2w/a + b), where w is the sum of the minor score for species that are present in both communities, a is the sum of the taxa measures in a community, and b is the sum of taxa measures in the other community. The distance index was significantly increased post-COS