Table 3.
Randomized controlled studies comparing the efficacy of IVF vs. ICSI in couples with non-male infertility
| N | Fertilization rate (%) | p | Pregnancy rate (%) | p | Live born rates | p | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IVF | ICSI | IVF | ICSI | IVF | ICSI | ||||||
| Aboulghar et al., 1996 | RCT tubal factor | 22 | 64.8 | 70 | ns | 32.0 | 38.0 | ns | – | – | – |
| Aboulghar et al., 1999 | RCT unexplained infertility | 116 | 64.8 | 53.3 | nr | 31.0 | 32.8 | nr | – | – | – |
| Moreno et al., 1998 | RCT poor responders | 96 | 70.2 | 77.7 | ns | 17.3 | 21.1 | ns | – | – | – |
| Bukulmez et al., 2000 | RCT tubal factor | 76 | 67.3 | 69.3 | ns | 21.5 | 21.5 | ns | 15.79 | 18.42 | ns |
| Bhattacharya et al., 2001 | RCT couples with non-male factor infertility | 415 | 58 | 48 | < 0.05 | 33.0 | 26.0 | < 0.05 | – | – | – |
| Poehl et al., 2001 | RCT tubal infertility or hostile cervical mucus | 89 | – | – | – | 33.0 | 23.0 | – | – | – | – |
| Hariprashad et al., 2002 | RCT failed fertilization cycles | 75 | 44.7 | 77 | < 0.05 | 10.7 | 34.1 | < 0.05 | – | – | – |
| Foong et al., 2006 | RCT unexplained infertility | 60 | 77.2 | 82.4 | ns | 50.0 | 50.0 | ns | 46 | 50 | ns |
IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, RCT randomized controlled trial, ns not significant