Table 4.
Diagnostic performance of FIT according to different cut-off values.
| FIT ≥20 μg/g | TP | FP | TN | FN | Se (95%CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | OR* (95%CI) |
|---|---|---|---|---|---|---|---|---|---|
| Any Lesion | 127 | 61 | 405 | 134 | 48.7% (42.7–54.7) | 86.9% (83.5–89.7) | 67.6% (60.6–73.8) | 75.1% (71.3–78.6) | 5.8 (4.0–8.3) |
| Clinically significant pathology | 97 | 91 | 494 | 45 | 68.3% (60.3–75.4) | 84.4% (81.3–87.2) | 51.6% (44.5–58.6) | 91.7% (89.0–93.7) | 10.7 (7.0–16.4) |
| Neoplasia | 98 | 90 | 455 | 84 | 53.8% (46.6–60.9) | 83.5% (80.1–86.4) | 52.1% (45.0–59.2) | 84.4% (81.1–87.2) | 5.2 (3.6–7.7) |
| Advanced neoplasia | 77 | 111 | 501 | 38 | 67.0% (57.9–74.9) | 81.9% (78.6–84.7) | 41.0% (34.2–48.1) | 92.9% (90.5–94.8) | 8.2 (5.2–12.9) |
| Cancer | 33 | 155 | 536 | 3 | 91.7% (78.2–97.1) | 77.6% (74.3–80.5) | 17.6% (12.8–23.6) | 99.4% (98.4–99.8) | 31.4 (9.5–104.5) |
| FIT ≥10 μg/g | TP | FP | TN | FN | Se (95%CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | OR* (95%CI) |
| Any Lesion | 135 | 71 | 395 | 126 | 51.7% (45.7–57.7) | 84.8% (81.2–87.7) | 65.5% (58.8–71.7) | 75.8% (72.0–79.3) | 5.4 (3.8–7.7) |
| Clinically significant pathology | 104 | 102 | 483 | 38 | 73.2% (65.4–79.8) | 82.6% (79.3–85.4) | 50.5% (43.7–57.2) | 92.7% (90.1–94.6) | 11.8 (7.6–18.2) |
| Neoplasia | 104 | 102 | 443 | 78 | 57.1% (49.9–64.1) | 81.3% (77.8–84.3) | 50.5% (43.7–57.2) | 85.0% (81.7–87.8) | 5.0 (3.5–7.4) |
| Advanced neoplasia | 82 | 124 | 488 | 33 | 71.3% (62.5–78.8) | 79.7% (76.4–82.7) | 39.8% (33.4–46.6) | 93.7% (91.2–95.5) | 8.5 (5.4–13.6) |
| Cancer | 34 | 172 | 519 | 2 | 94.4% (81.9–98.5) | 75.1% (71.8–78.2) | 16.5% (12.1–22.2) | 99.6% (98.6–99.9) | 41.7 (9.9–176.5) |
| p-value+ | |||||||||
| Any lesion | 0.005 | 0.002 | 0.081 | 0.112 | |||||
| Clinically significant pathology | 0.008 | 0.001 | 0.305 | 0.021 | |||||
| Neoplasia | 0.014 | 0.001 | 0.131 | 0.126 | |||||
| Advanced neoplasia | 0.025 | <0.001 | 0.253 | 0.067 | |||||
| Cancer | 0.317 | <0.001 | 0.071 | 0.350 |
*
OR: risk of presenting the outcome with a positive FIT compared to a negative FIT. Adjusted by sex and age.
+
p value refers to the comparison of Se, Sp, PPV and NPV with the two cut-off values for the different outcomes.
Bold values highlight the statistically significant data.