Table 5.
Diagnostic performance of FIT according to location and cut-off value.
| FIT ≥20 μg/g | TP | FP | TN | FN | Se (95%CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | OR* (95%CI) |
|---|---|---|---|---|---|---|---|---|---|
| Cancer | 33 | 155 | 536 | 3 | 91.7% (78.2–97.1) | 77.6% (74.3–80.5) | 17.6% (12.8–23.6) | 99.4% (98.4–99.8) | 31.4 (9.5–104.5) |
| Right-sided colon | 10 | 178 | 538 | 1 | 90.9% (62.3–98.4) | 75.1% (71.8–78.2) | 5.3% (2.9–9.5) | 99.8% (99.0–100.0) | 22.5 (2.8–179.1) |
| Left-sided colon | 10 | 178 | 537 | 2 | 83.3% (55.2–95.3) | 75.1% (71.8–78.1) | 5.3% (2.9–9.5) | 99.6% (98.7–99.9) | 11.4 (2.5–53.2) |
| Rectum | 13 | 175 | 539 | 0 | 100.0% (77.2–100.0) | 75.5% (72.2–78.5) | 6.9% (4.1–11.5) | 100.0% (99.3–100.0) | – |
| Left-sided colon + rectum | 23 | 165 | 537 | 2 | 92.0% (75.0–97.8) | 76.5% (73.2–79.5) | 12.2% (8.3–17.7) | 99.6% (98.7–99.9) | 31.4 (7.3–135.3) |
| Advanced neoplasia | 77 | 111 | 501 | 38 | 67.0% (57.9–74.9) | 81.9% (78.6–84.7) | 41.0% (34.2–48.1) | 92.9% (90.5–94.8) | 8.2 (5.2–12.9) |
| Right-sided colon | 20 | 168 | 527 | 12 | 62.5% (45.3–77.1) | 75.8% (72.5–78.9) | 10.6% (7.0–15.9) | 97.8% (96.1–98.7) | 4.3 (2.0–9.1) |
| Left-sided colon | 36 | 152 | 520 | 19 | 65.5% (52.3–76.6) | 77.4% (74.1–80.4) | 19.1% (14.2–25.4) | 96.5% (94.6–97.7) | 5.4 (3.0–9.8) |
| Rectum | 21 | 167 | 532 | 7 | 75.0% (56.6–87.3) | 76.1% (72.8–79.1) | 11.2% (7.4–16.5) | 98.7% (97.3–99.4) | 8.4 (3.5–20.3) |
| Left-sided colon + rectum | 57 | 131 | 513 | 26 | 68.7% (58.1–77.6) | 79.7% (76.4–82.6) | 30.3% (24.2–37.2) | 95.2% (93.0–96.7) | 7.5 (4.5–12.6) |
| FIT ≥10 μg/g | TP | FP | TN | FN | Se (95%CI) | Sp (95%CI) | PPV (95%CI) | NPV (95%CI) | OR* (95%CI) |
| Cancer | 34 | 172 | 519 | 2 | 94.4% (81.9–98.5) | 75.1% (71.8–78.2) | 16.5% (12.1–22.2) | 99.6% (98.6–99.9) | 41.7 (9.9–176.5) |
| Right-sided colon | 10 | 196 | 520 | 1 | 90.9% (62.3–98.4) | 72.6% (69.2–75.8) | 4.9% (2.7–8.7) | 99.8% (98.9–100.0) | 19.3 (2.4–154.1) |
| Left-sided colon | 11 | 195 | 520 | 1 | 91.7% (64.6–98.5) | 72.7% (69.3–75.9) | 5.3% (3.0–9.3) | 99.8% (98.9–100.0) | 21.9 (2.8–172.6) |
| Rectum | 13 | 193 | 521 | 0 | 100.0% (77.2–100.0) | 73.0% (69.6–76.1) | 6.3% (3.7–10.5) | 100.0% (99.3–100.0) | – |
| Left-sided colon + rectum | 24 | 182 | 520 | 1 | 96.0% (80.5–99.3) | 74.1% (70.7–77.2) | 11.7% (8.0–16.8) | 99.8% (98.9–100.0) | 57.0 (7.6–426.9) |
| Advanced neoplasia | 82 | 124 | 488 | 33 | 71.3% (62.5–78.8) | 79.7% (76.4–82.7) | 39.8% (33.4–46.6) | 93.7% (91.2–95.5) | 8.5 (5.4–13.6) |
| Right-sided colon | 20 | 186 | 509 | 12 | 62.5% (45.3–77.1) | 73.2% (69.8–76.4) | 9.7% (6.4–14.5) | 97.7% (96.0–98.7) | 3.7 (1.7–7.8) |
| Left-sided colon | 40 | 166 | 506 | 15 | 72.7% (59.8–85.7) | 75.3% (71.9–78.4) | 19.4% (14.6–25.4) | 97.1% (95.3–98.2) | 6.7 (3.6–12.6) |
| Rectum | 22 | 184 | 515 | 6 | 78.6% (60.5–89.8) | 73.7% (70.3–76.8) | 10.7% (7.2–15.6) | 98.8% (97.5–99.5) | 8.9 (3.5–22.6) |
| Left-sided colon + rectum | 62 | 144 | 500 | 21 | 74.7% (64.4–82.8) | 77.6% (74.3–80.7) | 30.1% (24.2–36.7) | 96.0% (93.9–97.3) | 8.8 (5.1–15.2) |
*
OR: risk of presenting the outcome with a positive FIT compared to a negative FIT. Adjusted by sex and age.