Table 7.

Diagnostic performance of FIT + symptom for advanced neoplasia.

FIT ≥20 μg/g	TP	FP	TN	FN	Se (95%CI)	Sp (95%CI)	PPV (95%CI)	NPV (95%CI)	OR* (95%CI)
FIT	77	111	501	38	67.0% (57.9–74.9)	81.9% (78.6–84.7)	41.0% (34.2–48.1)	92.9% (90.5–94.8)	8.2 (5.2–12.9)
FIT + Rectal bleeding	31	32	580	84	27.0% (19.7–35.7)	94.8% (92.7–96.3)	49.2% (37.3–61.2)	87.3% (84.6–89.7)	7.4 (4.1–13.4)
FIT + Change in bowel habits	5	10	602	110	4.3% (1.9–9.8)	98.4% (97.0–99.1)	33.3% (15.2–58.3)	84.6% (81.7–87.0)	2.0 (0.6–6.4)
FIT + Diarrhea	7	17	595	108	6.1% (3.0–12.0)	97.2% (95.6–98.3)	29.2% (14.9–49.2)	84.6% (81.8–87.1)	2.7 (1.0–7.3)
FIT + Abdominal pain	6	16	596	109	5.2% (2.4–10.9)	97.4% (95.8–98.4)	27.3% (13.2–48.2)	84.5% (81.7–87.0)	1.8 (0.7–5.0)
FIT + Anemia	21	24	588	94	18.3% (12.3–26.3)	96.1% (94.2–97.4)	46.7% (32.9–60.9)	86.2% (83.4–88.6)	3.6 (1.8–6.9)
FIT ≥10 μg/g	TP	FP	TN	FN	Se (95%CI)	Sp (95%CI)	PPV (95%CI)	NPV (95%CI)	OR* (95%CI)
FIT	82	124	488	33	71.3% (62.5–78.8)	79.7% (76.4–82.7)	39.8% (33.4–46.6)	93.7% (91.2–95.5)	8.5 (5.4–13.6)
FIT + Rectal bleeding	33	37	575	82	28.7% (21.2–37.5)	94.0% (91.8–95.6)	47.1% (35.9–58.7)	87.5% (84.8–89.8)	6.7 (3.8–11.7)
FIT + Change in bowel habits	7	14	598	108	6.1% (3.0–12.0)	97.7% (96.2–98.6)	33.3% (17.2–54.6)	84.7% (81.9–87.2)	2.4 (0.9–6.4)
FIT + Diarrhea	7	18	594	108	6.1% (3.0–12.0)	97.1% (95.4–98.1)	28.0% (14.3–47.6)	84.6% (81.8–87.1)	2.1 (0.8–5.5)
FIT + Abdominal pain	6	17	595	109	5.2% (2.4–10.9)	97.2% (95.6–98.3)	26.1% (12.5–46.5)	84.5% (81.7–87.0)	1.8 (0.7–4.8)
FIT + Anemia	21	25	587	94	18.3% (12.3–26.3)	95.9% (94.0–97.2)	45.7% (32.2–59.8)	86.2% (83.4–88.6)	3.4 (1.8–6.6)

^*OR: risk of presenting advanced neoplasia with a positive FIT compared to a negative FIT. Adjusted by sex and age.