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. 2020 Sep 2;8:679. doi: 10.3389/fbioe.2020.00679

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Copyright © 2020 Xueqing, Jun, Yueqiang, Xin, Liya, Yuanyuan, Yuting, Hao, Hua, Jian and Tiejun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IGF2BP3 regulates multiple alternative splicing events. (A) IGF2BP3 expression on mRNA and protein level in A549 cells after transiently transfected with IGF2BP3 specific overexpression RNA or control vector, as determined by qRT-PCR and Western blot analysis. (B) Total number of differentially expressed genes. (C) Hierarchical clustering of DEGs in overexpressed and control samples. Expression values (FPKM) are log2-transformed and then median-centered by each gene. (D,E) The top 10 representative GO Biological Process terms of IGF2BP3-regulated genes. (F) Classification of different AS types regulated by IGF2BP3 protein. (G) The top 10 GO Pathways for gene aggregation of differential AS events.