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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: J Hum Hypertens. 2020 Apr 24;34(9):617–623. doi: 10.1038/s41371-020-0340-6

Table 3.

Number of Medicare prescriptions dispensed for each antihypertensive fixed-dose combination product in the United States in 2018.

Antihypertensive medication class combination Generic name
Brand name		 Generic dispenses Brand dispenses
ACEI/thiazide diuretic Lisinopril/HCTZ
Zestoretic®		 6,794,908 2,021
Benazepril/HCTZ
Lotensin HCT®		 384,946 68
Enalapril/HCTZ
Vaseretic®		 199,297 18
Quinapril/HCTZ
Accuretic™		 105,208 932
Fosinopril/HCTZ
Monopril HCT		 19,972 0
Captopril/HCTZ
(none)		 13,149 0
Moexipril/HCTZ
Uniretic®		 10,290 0
ARB/thiazide diuretic Losartan/HCTZ
Hyzaar®		 7,212,362 9,891
Valsartan/HCTZ
Diovan HCT®		 2,347,400 21,627
Irbesartan/HCTZ
Avalide®		 555,805 3,793
Olmesartan/HCTZ
Benicar HCT®		 700,911 35,271
Telmisartan/HCTZ
Micardis HCT		 167,794 7,668
Candesartan/HCTZ
Atacand HCT®		 56,500 3,072
Azilsartan/chlorthalidone
Edarbyclor		 0 67,752
ACEI/CCB Benazepril/amlodipine
Lotrel		 1,892,257 8,572
Trandolapril/verapamil [controlled release]
Tarka		 8,173 3,344
Perindopril/amlodipine
Prestalia		 0 14
ARB/CCB Valsartan/amlodipine
Exforge		 360,471 10,289
Olmesartan/amlodipine
Azor®		 212,891 14,114
Telmisartan/amlodipine
Twynsta®		 686,682 279
ARB/CCB/thiazide diuretic Olmesartan/amlodipine/HCTZ
Tribenzor®		 138,913 8,297
Valsartan/amlodipine/
HCTZ
Exforge HCT®		 87,652 2,499
Beta-blocker/thiazide diuretic Bisoprolol/HCTZ
Ziac®		 756,170 1,052
Atenolol/chlorthalidone
Tenoretic		 546,542 507
Metoprolol tartrate/HCTZ
Lopressor HCT®		 57,550 0
Propranolol/HCTZ
(none)		 5,968 0
Nadolol/
Bendroflumethazide
Corzide®		 1,713 115
Metoprolol succinate/HCTZ
Dutoprol®		 0 1,237
Potassium-sparing diuretic/thiazide diuretic Triamterene/HCTZ
Dyazide®, Maxzide®		 3,880,450 9,300
Amiloride/HCTZ
(none)		 71,435 0
Aldosterone antagonist/thiazide diuretic Spironolactone/HCTZ
Aldactazide®		 265,366 1,064
Alpha-2-agonist/thiazide diuretic Methyldopa/HCTZ
(none)		 812 0
Direct renin inhibitor/thiazide diuretic Aliskiren/HCTZ
Tekturna HCT		 0 13,210

ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker; CCB: calcium channel antagonist; HCTZ: hydrochlorothiazide; rx: prescription

Utilization data were generated from the 2014–2018 Medicare Part D Drug Spending Data available from the Centers for Medicaid and Medicare Services (https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/Information-on-Prescription-Drugs/MedicarePartD).