Table 1.
Characteristics of analytic cohort
| Characteristic | Total (n=8068) |
Framingham ARIC (n=2056) |
Offspring (n=6012) |
P-value |
|---|---|---|---|---|
| Age (median 25th 75th, years) | 58, ( 55-62) | 54, (50-60) | 59, (56-62) | <.001 |
| Female (n, %) | 4556 (56.5%) | 1111 (54.0%) | 3445 (57.3%) | 0.010 |
| White (n, %) | 6790 (84.2%) | 2056 (100.0%) | 4734 (78.7%) | <.001 |
| Smoking (n, %) | 1308 (16.3%) | 336 (16.3%) | 972 (16.2%) | 0.912 |
| Diabetes (n, %) | 970 (12.1%) | 123 (6.0%) | 847 (14.1%) | <.001 |
| Systolic BP (median 25th and 75th, mmHg) | 122, 112-135 | 123, 112-135 | 122, 112-135 | 0.486 |
| Diastolic BP (median 25th and 75th, mmHg) | 73, 66-79 | 76, 70-82 | 72, 65-78 | <.001 |
| BMI (median 25th and 75th) | 28, 25-31 | 28, 25-31 | 28, 25-32 | <.001 |
| Ounces of Ethanol per week | 0, 0-2 | 1, 0-3 | 0, 0-1 | <.001 |
| Hypertension treatment (n, %) | 2170 (27.0%) | 393 (19.1%) | 1777 (29.7%) | <.001 |
| Lipid Lowering Medication (n, %) | <.001 | |||
| On Statin | 629 (7.8%) | 120 (5.8%) | 509 (8.5%) | |
| Not on Statin, on other lipid lowering medication | 161 (2.0%) | 31 (1.5%) | 130 (2.2%) | |
| No lipid lowering medicaiton | 7623 (90.2%) | 1904 (92.7%) | 5359 (89.3%) | |
| Fasting Glucose | 99, 92-108 | 96, 90-104 | 99, 93-109 | <.001 |
| Total cholesterol (median 25th and 75th, mg/dL) | 200, 178-225 | 204, 181-230 | 199, 177-224 | <.001 |
| HDL-C (median 25th and 75th, mg/dL) | 48, 39-61 | 50, 40-61 | 47, 39-60 | 0.003 |
| Non-HDL-C (medin 25th and 75th, mg/dL) | 149, 126-174 | 152, 127-178 | 148, 125-173 | <.001 |
| Triglyceride:HDL-C Ratio (medin 25th and 75th) | 2.29, 1.43-3.70 | 1.89, 1.18-3.08 | 2.44, 1.54-3.89 | <.001 |
| LDL-C (median 25th and 75th, mg/dL) | 122, 101-145 | 125, 104-148 | 121, 100-143 | <.001 |
| Average TG (median 25th and 75th, mg/dL) | 110, 82-154 | 94, 69-132 | 116, 86-160 | <.001 |
| Number of TG measurements pre-imputation | Mean: 4.4 | Mean: 5.8 | Mean: 4.0 | |
| Median: 4 | Median: 6 | Median: 4 | ||
| Follow-up time | 10 years | 10 years | 10 years |
ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; BP, blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride