Table 1.

CFTR Modulator Intracellular Concentration in HBE (F508del/F508del) Cells. Averages of ivacaftor, lumacaftor, and tezacaftor concentrations (μM) ± standard error of the mean. P-values were calculated for each modulator in comparison to the corresponding DMSO vehicle control.

	DMSO	Iva (Luma/Iva)	p-value	Iva (Teza/Iva)	p-value	Luma (Luma/Iva)	p-value	Teza (Teza/Iva)	p-value
1	0.00 ± 0.00	2.8 ± 0.49	0.0247	2.01 ± 0.3	0.0059	1.05 ±0.27	0.0598	1.64 ±0.11	<0.0001
7	0.00 ± 0.00	8.98 ± 0.76	<0.0001	10.86 ±1.01	<0.0001	1.47 ±0.13	<0.0001	2.95 ± 0.24	<0.0001
14	0.00 ± 0.00	20.96 ± 3.35	0.0041	20.33 ±2.4	0.0005	1.59 ±0.11	<0.0001	3.53 ±0.51	0.0021
15	0.00 ± 0.00	23.3 ± 2.98	0.0009	24.81 ± 3.65	0.0024	0.36 ± 0.04	0.0006	1.84 ±0.55	0.1268
21	0.00 ± 0.00	20.95 ± 2.9	0.0016	21.28 ±2.53	0.0005	0.03 ±0.01	0.2937	0.59 ±0.17	0.1217
28	0.00 ± 0.00	18.36 ±2.18	0.0005	18.55 ±1.83	0.0001	0.01 ± 0.00	0.3995	0.12 ±0.03	0.0781