TABLE 5.
Adjusted odds ratios. Logistic model. Outcomes: (a) early onset preeclampsia (EOP), (b) late onset preeclampsia (LOP). Preeclamptic women (n = 1736), vs controls (normotensive women, n = 71 090)
| Cut-off 30 weeks aOR | P value | Cut-off 32 weeks aOR | P value | Cut-off 34 weeks aOR | P value | Cut-off 37 weeks aOR | P value | |
|---|---|---|---|---|---|---|---|---|
| EOP | ||||||||
| Maternal age (increment/5 y of age) | 1.04 [1.01-1.07] | .005 | 1.05 [1.02-1.07] | <.0001 | 1.04 [1.02-1.06] | <.0001 | 1.04 [1.03-1.06] | <.0001 |
| BMI (increment/5 kg/m2) | 1.06 [1.03-1.09] | <.0001 | 1.05 [1.03-1.07] | <.0001 | 1.04 [1.02-1.05] | <.0001 | 1.035 [1.02-1.04] | <.0001 |
| Antecedent preeclampsia | 17.04 [10.5. 27.5] | <.0001 | 12.6 [8.3.19.3] | <.0001 | 12.8 [9.2-17.9] | <.0001 | 9.4 [7.2-12.4] | <.0001 |
| Coagulopathies | 3.85 [0.91-16.2] | .06 | 3.7 [1.16-12.2] | .02 | 2.95 [1.06-8.2] | .04 | 3.1 [1.5-6.12] | .001 |
| GDM | 0.42 [0.23-0.77] | .005 | 0.61 [0.4-0.93] | .02 | 0.73 [0.52-1.0] | .05 | 1.05 | .61 |
| IVF | 2.8 | .16 | 1.39 | .64 | 2.06 | .12 | – | – |
| Chronic HBP | 6.4 [3.8-10.82] | <.0001 | 6.0 [3.9-9.26] | <.0001 | 6.51 [4.6-9.2] | <.0001 | 6.2 [4.9-7.8] | <.0001 |
| Renal diseases | 0.0 | .94 | 1.25 | .77 | 1.43 | .53 | 1.43 | .53 |
| Primiparity | 2.16[1.2-3.7] | .005 | 2.6 [1.7-3.9] | <.0001 | 2.53 [1.9-3.4] | <.0001 | 2.38 [2.0-2.8] | <.0001 |
| ART pregnancy | 3.7 | .19 | 4.2 [1.01-17.7] | .05 | 3.9 [1.2-12.7] | .02 | – | – |
| Smoking | 0.66 | .19 | 0.76 | .27 | 0.89 | .52 | 0.80 [0.63-1.0] | .06 |
| Thyroid diseases | 1.18 | .17 | 1.26 | .61 | 1.39 | .33 | 1.32 | .20 |
| LOP | ||||||||
| Maternal age (increment/5 y of age) | 1.04 [1.03-1.06] | <.0001 | 1.04 [1.02-1.057] | <.0001 | 1.04 [1.02-1.04] | <.0001 | 1.038 [1.02-1.05] | <.0001 |
| BMI (increment/5 kg/m 2) | 1.044 [1.03-1.05] | <.0001 | 1.047 [1.04-1.06] | <.0001 | 1.05 [1.04-1.06] | <.0001 | 1.063 [1.05-1.07] | <.0001 |
| Antecedent preeclampsia | 8.27 [6.4-10.6] | <.0001 | 8.2 [6.3.10.6] | <.0001 | 7.11 [5.4-9.4] | <.0001 | 8.3 [5.8-11.9] | <.0001 |
| Coagulopathies | 2.35 [1.12-4.9] | .02 | 1.7 | .17 | 1.66 | .22 | 1.4 | .54 |
| GDM | 1.07 | .41 | 1.08 | .36 | 1.12 | .19 | 0.90 | .40 |
| IVF | 0.98 | .97 | 1.1 | .70 | 1.03 | .91 | 0.74 | .51 |
| Chronic HBP | 4.8 [3.8-6.1] | <.0001 | 4.7 [3.8-5.9] | <.0001 | 4.45 [3.5-5.6] | <.0001 | 3.4 [2.5-4.8] | <.0001 |
| Renal diseases | 2.17 [1.06-4.4] | .03 | 1.99 [1.04-3.8] | .04 | 2.02 [1.01-4.0] | .05 | 1.9 | .17 |
| Primiparity | 2.68 [2.2-3.3] | <.0001 | 2.7 [2.4-3.1] | <.0001 | 2.75 [2.4-3.2] | <.0001 | 3.3 [2.8-4.0] | <.0001 |
| ART pregnancy | 1.31 | .64 | 0.89 | .80 | 0.58 | .36 | 0.65 | .54 |
| Smoking | 0.89 | .30 | 0.76 [0.6-0.9] | .006 | 0.75 [0.6-0.9] | .008 | 0.72 [0.54-0.95] | .02 |
| Thyroid diseases | 1.02 | .91 | 1.07 | .74 | 0.94 | .81 | 0.79 | .50 |
ART, assisted reproductive technology; BMI, body mass index; GDM, gestational diabetes mellitus; HBP, high blood pressure; IVF, in vitro fertilization.