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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2020 Mar 16;146(4):884–893.e5. doi: 10.1016/j.jaci.2020.02.032

Figure 2. Omeprazole blocks IgE-induced human mast cell degranulation and cytokine secretion.

Figure 2.

Bar plots showing LAMP-1 expression (A) and histamine release (B) by human mast cells following sensitization with IgE, treatment with drug vehicle (DMSO) or omeprazole, and challenge with anti-IgE for 10 and 5 minutes, respectively. Secretion of PGD2 (C), IL-5 (D) and IL-13 (E) by IgE-sensitized human mast cells following omeprazole treatment and stimulation with anti-IgE for six hours. Statistical analysis by one-way analysis of variance. *P<0.05, **P<0.01, ***P<0.001, and ****P<0.0001.