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. 2020 Apr 27;27(10):2768–2780. doi: 10.1038/s41418-020-0541-0

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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Western blot analysis of cIAP1, cIAP2, and XIAP protein expression in the indicated ER⁺ and TNBC PDX models. For each PDX, two lysates from independent mice are represented. b Western blot analysis of cIAP1 and cIAP2 protein expression in lysates from ER⁺ PDX-23 and TNBC PDX-110 cell suspensions treated with 1 μM of birinapant for 2 h. c Western blot analysis of NIK, p100/p52 protein expression in indicated breast cancer cell lines treated at indicated times with 1 μM of CompA (CpA) or with 100 ng/ml of TNF. d Levels of cIAP2 transcripts relative to GAPDH transcripts in indicated breast cancer cell lines treated with 1 μM of CompA (CpA) for 24 h or 48 h or with 100 ng/ml of TNF for 24 h. The caspase inhibitor IDN-6556 (5 μM) was added in all conditions to inhibit cell death. Bars represent mean ± SD of duplicates of one representative experiment. e Western blot analysis of cleaved caspase-3 (CC3), cleaved caspase-8 (CC8) and PARP in lysates from indicated breast cancer cell lines treated with 1 μM of birinapant (bir) or CompA (CpA) for 24 h. Tubulin (a, b) and actin (c, e) were used as loading controls.