Table 3.
Two-sample MR analyses of FGF23 and related bone metabolism trait levels.
| MR estimates, per unit increase in log odds of having FGF23 | MR-Egger regression | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IVW | Weighted median | Intercept | MR-Egger | ||||||||
| Outcomes | SNPs n | Data Source, sample size | β (se) | P-value | P-heterogeneity | β (se) | P-value | β (se) | P-value | β (se) | P-value |
| Ca | 5 | MRC-IEU 64,979 | 0.066 (0.073) | 0.366 | 0.609 | 0.035 (0.088) | 0.689 | −0.005 (0.014) | 0.709 | 0.050 (0.348) | 0.886 |
| P | 5 | MRC-IEU 463,010 | <0.001 (<0.001) | 0.866 | 0.174 | <0.001 (<0.001) | 0.650 | 0.000 (0.000) | 0.220 | −0.001 (0.001) | 0.385 |
| VD | 5 | MRC-IEU 64,979 | −0.080 (0.075) | 0.284 | 0.728 | −0.095 (0.089) | 0.289 | −0.016 (0.015) | 0.270 | 0.402 (0.353) | 0.254 |
| Cr | 5 | CKDGen 24,810 | 0.015 (0.123) | 0.898 | 0.026 | 0.027 (0.074) | 0.715 | −0.144 (0.424) | 0.735 | 4.390 (10.885) | 0.687 |
| Mg | 5 | MRC-IEU 64,979 | 0.013 (0.087) | 0.874 | 0.217 | 0.049 (0.099) | 0.616 | −0.016 (0.016) | 0.310 | 0.445 (0.381) | 0.243 |
| OA | 5 | MRC-IEU 501,405 (case, 38,472/control, 462,933) | −0.001 (0.009) | 0.944 | 0.218 | 0.001 (2.874) | 0.941 | 0.000 (0.002) | 0.979 | 0.011 (0.037) | 0.759 |
Cr, serum creatinine; P, serum phosphorus; Ca, Calcium; Mg, Magnesium; OA, Osteoarthritis; VD, Vitamin D; SNP, single nucleotide polymorphism; MR, Mendelian Randomization; SD, standard deviation; CKDGen, CKDGen Consortium; MRC-IEU, The Medical Research Council Integrative Epidemiology Unit (http://www.bristol.ac.uk/integrative-epidemiology/).