Table 2.
The CLDN18-ARHGAP fusion models in reported studies.
| Study |
Number of CLDN18-ARHGAP fusion |
Fusion Mode |
Numbers (%) |
|
|---|---|---|---|---|
| Nakayama et al. (7) | 22 | CLDN18/exon5 | ARHGAP26/exon10 | 18 (81.8) |
| ARHGAP26/exon 12 | ||||
| CLDN18/exon5 | ARHGAP6/exon2 | 2 (9.1) | ||
| CLDN18/exon5 | ARHGAP42/exon7 | 1 (4.5) | ||
| CLDN18/exon5 | ARHGAP10/exon8 | 1 (4.5) | ||
| Shu et al. (6) | 73 | CLDN18/exon5 | ARHGAP26/exon12 | 58 (79.5) |
| CLDN18/exon5 | ARHGAP26/exon10 | 7 (9.6) | ||
| CLDN18/exon4 | ARHGAP26/exon11 | 1 (1.4) | ||
| CLDN18/exon5 | ARHGAP6/exon2 | 7 (9.6) | ||
| Tanake et al. (8) | 26 | CLDN18/exon5 | ARHGAP26/exon12 | 24 (92.3) |
| CLDN18/exon5 | ARHGAP26/exon10 | 1 (3.8) | ||
| CLDN18/exon5 | ARHGAP6/exon2 | 1 (3.8) | ||
| Yang et al. (9) | 17 | CLDN18 | ARHGAP26 | 13 (76.5) |
| CTNND1 | ARHGAP26* | 2 (11.8) | ||
| ANXA2 | MYO9A* | 2 (11.8) | ||
| TCGA (4) | 13 | CLDN18/exon5 | ARHGAP26/exon12 | 10 (76.9) |
| CLDN18/exon5 | ARHGAP26/exon10 | 1 (7.7) | ||
| CLDN18/exon5 | ARHGAP6/exon2 | 2 (15.4) | ||
TCGA, The Cancer Genome Atlas.
*
Also known as RhoGAP domain-containing fusions.