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. 2020 Sep 2;11:2135. doi: 10.3389/fimmu.2020.02135

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Copyright © 2020 Nishikoba, Kumagai, Kanmura, Nakamura, Ono, Eguchi, Kamibayashiyama, Oda, Mawatari, Tanoue, Hashimoto, Tsubouchi and Ido.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HGF-MET signaling shifts M1 macrophage intracellular metabolism to an M2-like phenotype. Effect of HGF treatment on macrophage intracellular metabolism. RT-qPCR was used to analyze mRNA expression of genes involved in glucose metabolism (Slc2a1, hexokinase, and pyruvate kinase), amino acid metabolism (Slc1a5, glutaminase, and glutamate dehydrogenase), and fatty acid metabolism (CD36, fatty acid synthase, and acyl-CoA synthase-1). The Ct values were normalized to those of β-actin and have been expressed relative to mean level in M0 macrophages not treated with HGF, which is arbitrarily defined as 1. The data are represented as the mean and a scatterplot showing individual data points (n = 4). Unpaired Student's t-test, *P < 0.05 and **P < 0.01.