Table 1.

Definitions of IOF and RE-AIM outcomes.

Implementation Outcome	Definition
a. Acceptability	IOF: The perception among implementation stakeholders that a given treatment, service, practice, or innovation is agreeable, palatable, or satisfactory RE-AIM: N/A
b. Adoption	IOF: The intention, initial decision, or action to try or employ an innovation or evidence-based practice RE-AIM: The number, proportion, and representativeness of organizations or settings that agree to deliver the intervention, as well as the number, proportion, representativeness, and expertise of individuals in those settings that would ultimately deliver the intervention
c. Appropriateness	IOF: The perceived fit, relevance, or compatibility of the innovation or evidence-based practice for a given practice setting, provider, or consumer; and/or perceived fit of the innovation to address a particular issue or problem RE-AIM: N/A
d. Attributable individual level impact	IOF: N/A RE-AIM: Population Prevalence X Individual Level Impact (see Row l. below for definition)
e. Attributable organizational level impact	IOF: N/A RE-AIM: Population Prevalence X Organizational Level Impact (see Row o. below for definition)
f. Composite individual and organizational level impact	IOF: N/A RE-AIM: Reach + Effectiveness (or individual level Maintenance) + Adoption + Implementation/4 Maintenance (see below for detailed equations)
g. Costs	IOF: The cost impact of an implementation effort and of implementation strategies RE-AIM: Costs related to implementation and cost-effectiveness assessment
h. Effectiveness	IOF: N/A RE-AIM: A measurement of the degree to which the intervention is producing its intended effects while assessing potential unintended consequences and changes in quality of life
i. Feasibility	IOF: The extent to which a new treatment, or an innovation, can be successfully used or carried out within a given agency or setting RE-AIM: N/A
j. Fidelity	IOF: The degree to which an intervention was implemented as it was prescribed in the original protocol or as it was intended by the program developers RE-AIM: A component of implementation
k. Implementation	IOF: Aligns with Fidelity RE-AIM: Measures of cost and the degree to which the intervention is implemented with fidelity
l. Individual level impact (RE1)	IOF: N/A RE-AIM: Reach X composite Effectiveness = (participation rate - median ESdifferential characteristics) X (median ESkey outcomes - median ESnegative outcomes - median ESdifferential impact)
m. Individual level impact efficiency	IOF: N/A RE-AIM: (Incremental cost of treatment - control)/(incremental RE1 of treatment - control)
n. Maintenance	IOF: Included as sustainability RE-AIM: Considered at both the individual (maintenance of health outcomes ≥6 months post-intervention) and the setting (the degree to which the intervention has been institutionalized or sustainably adopted) levels
o. Organizational level impact AI1	IOF: N/A RE-AIM: (Organizational adoption rate - median ESdifferential setting characteristics) X (staff adoption rate X median ESdifferential staff characteristics) X (median component implementation rate across staff and Tx components - median ESdifferential implementation)
p. Penetration	IOF: The integration of a practice within a service setting and its subsystems. Later definitions included integration within service recipients (i.e., reach) (7) RE-AIM: A component of adoption and, if service recipients included, reach
q. Reach	IOF: Included if service recipients included in penetration RE-AIM: The absolute number, proportion, and representativeness of individuals who are willing to participate in a given initiative, intervention, or program, and reasons why or why not
r. Sustainability	IOF: The extent to which a newly implemented treatment is maintained or institutionalized within a service setting's ongoing, stable operations RE-AIM: Included as organizational maintenance of intervention implementation or institutionalization