Table 3.
Characteristics of patients according to different complement deposition.
| Variables |
C4c+C3c+C1q+ (n = 15) |
C4c+C3c+C1q-/C4+C3-C1q+ (n = 5) |
C4c- (n = 59) |
p-value |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Urinary protein (g/d) | 7.3 (2.68, 13.01) | 5.59 (1.78, 9.56) | 2.62 (1.77, 5.73)a | 0.021 |
| eGFR (ml/min/1.73 m2) |
41 (28, 82) | 55 (34, 87.5) | 65 (38, 81) | 0.329 |
| Scr (umol/L) | 158.7 (89.2, 215.8) | 122.4 (81.3, 247.85) | 110.4 (90.8, 159.5) | 0.233 |
| Pathological characteristics | ||||
| Glomerular class (I/IIa/IIb/III/IV) | 0/0/2/8/5 | 0/0/1/3/1 | 0/4/14/30/11 | 0.256 |
| IFTA score (0/1/2/3) | 0/1/4/10 | 0/0/3/2 | 1/15/19/24 | 0.122 |
| Interstitial inflammation score (0/1/2) | 0/5/10 | 0/1/4 | 4/37/18a | 0.006 |
| Vascular lesion score (0/1/2) | 5/5/5 | 2/3/0 | 23/19/17 | 0.664 |
| Global sclerosis (%) | 39.83 ± 19.9 | 31.38 ± 19.81 | 30.70 ± 27.46 | 0.476 |
eGFR, estimated glomerular filtration rate; Scr, serum creatine; IFTA, interstitial fibrosis and tubular atrophy; C1q, complement 1q; C3, complement 3; C4, complement 4.
Continuous variables were presented as means ± standard deviation or medians (interquartile range), categorical variables as n (%). The p value with statistics significant (two-tailed p < 0.05) in the tables were marked bold. Other bold values were parameters for different classification.
a
Two-tailed p < 0.05 (compared to C4c+C3c+C1q+, post-hoc).