Table 4.
Characteristics of patients according to C4c deposition and/or C4 levels.
| Variables |
Lower C4 level & no C4c deposition (n = 29) |
Lower C4 level & C4c deposition (n = 11) |
Higher C4 level & no C4c deposition (n = 30) |
Higher C4 level & C4c deposition (n = 9) |
p-value |
|---|---|---|---|---|---|
| Clinical characteristics | |||||
| Urinary protein (g/d) | 2.74 (1.69, 4.88)a | 2.68 (1.84, 11.51) | 2.49 (1.77, 6.51)a | 7.3 (6.04, 19.58) | 0.006 |
| eGFR (ml/min/1.73 m2) |
68 (39, 80.5) | 52 (30, 89) | 62 (37.75, 91.25) | 41 (27, 68.5) | 0.495 |
| Scr (umol/L) | 103.9 (92.35, 137.55) | 122.4 (81.4, 209.2) | 113.45 (86.48, 175.53) | 158.7 (106.85, 219) | 0.38 |
| Pathological characteristics | |||||
| Glomerular class (I/IIa/IIb/III/IV) | 0/4/5/13/7 | 0/0/3/6/2 | 0/0/9/17/4 | 0/0/0/5/4 | 0.158 |
| IFTA Score (0/1/2/3) | 0/8/9/12 | 0/1/4/6 | 1/7/10/12 | 0/0/3/6 | 0.242 |
| Interstitial inflammation score (0/1/2) | 3/18/8a | 0/5/6 | 1/19/10b | 0/1/8 | 0.006 |
| Vascular lesion Score (0/1/2) | 14/8/7 | 2/6/3 | 9/11/10 | 5/2/2 | 0.352 |
| Global sclerosis (%) | 33.83 ± 28.32 | 36.69 ± 21.8 | 27.67 ± 26.74 | 38.97 ± 18.04 | 0.583 |
eGFR, estimated glomerular filtration rate; Scr, serum creatine; IFTA, interstitial fibrosis and tubular atrophy; C4, complement 4.
Continuous variables were presented as means ± standard deviation or medians (interquartile range), categorical variables as n (%). The p value with statistics significant (two-tailed p < 0.05) in the tables were marked bold. Other bold values were parameters for different classification.
a
Two-tailed p < 0.01 (compared to Higher C4 level & C4c deposition, post-hoc).
b
Two-tailed p < 0.05 (compared to Higher C4 level & C4c deposition, post-hoc).