Table 2.
Exposures | MR | Heterogeneity | Pleiotropy | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Method | beta | SE | p | Method | Q | p | Intercept | SE | p | |
Coronary heart disease | MR Egger | 0.3032 | 0.8636 | 0.759 | MR-Egger | 1.623 | 0.446 | −0.0074 | 0.021 | 0.755 |
WM | 0.06446 | 0.319 | 0.8398 | |||||||
IVW | 0.008949 | 0.2636 | 0.9729 | IVW | 1.742 | 0.623 | ||||
RAPS | 0.00909 | 0.2757 | 0.9737 | |||||||
Myocardial infarction | MR Egger | −0.2609 | 0.9332 | 0.8061 | MR-Egger | 1.369 | 0.526 | 0.0076 | 0.022 | 0.766 |
WM | 0.03509 | 0.3512 | 0.9204 | |||||||
IVW | 0.0411 | 0.2897 | 0.8872 | IVW | 1.475 | 0.692 | ||||
RAPS | 0.04163 | 0.3019 | 0.8903 | |||||||
Cardioembolic stroke | MR Egger | −1.429 | 3.887 | 0.7485 | MR-Egger | 2.145 | 0.346 | 0.054 | 0.089 | 0.602 |
WM | 0.3764 | 1.205 | 0.7547 | |||||||
IVW | 0.8811 | 0.942 | 0.3496 | IVW | 2.536 | 0.475 | ||||
RAPS | 0.902 | 1.001 | 0.3677 | |||||||
Ischemic stroke | MR Egger | 0.3005 | 1.82 | 0.8841 | MR-Egger | 1.236 | 0.536 | −0.0033 | 0.042 | 0.945 |
WM | −0.04136 | 0.5576 | 0.9409 | |||||||
IVW | 0.1628 | 0.4678 | 0.7278 | IVW | 1.425 | 0.742 | ||||
RAPS | 0.1649 | 0.4878 | 0.7354 |
WM, Weighted median; IVW, Inverse variance weighted; SE, standard error; beta, beta-coefficients; MR, Mendelian randomization; RAPS, Robust Adjusted Profile Score.