Figure 7.

Schematic summary: RvE1 attenuates polymicrobial sepsis-induced cardiac dysfunction and enhances bacterial clearance. The upper panel displays substantial reduction of multiple SPMs, particularly RvE1, in the heart of mice with polymicrobial sepsis, and this reduction was associated with the development of profound cardiac dysfunction. The lower panel shows delayed therapeutic administration of RvE1 attenuated polymicrobial sepsis-induced cardiac dysfunction and augmented bacterial clearance, and its associated mechanisms as demonstrated in vivo and in vitro.