Table 3.

Univariable and multivariable cox regression analysis of the sequence of chemotherapy and immunotherapy.

		Univariate analysis		Multivariable analysis
		HR (95% CI)	P	HR (95% CI)	P
A: Chemotherapy plus immunotherapy regardless of RT (n = 705)
CTx plus immunotherapy	CTx and Immx within 30 days	Ref		Ref
	Immx 31–90 days before CTx	1.179 (0.815–1.705)	0.384	1.057 (0.716–1.561)	0.781
	Immx 91–180 days before CTx	0.901 (0.611–1.329)	0.598	0.900 (0.584–1.388)	0.635
B: Only chemotherapy plus immunotherapy sample (n = 479)
CTx plus immunotherapy	CTx and immx within 30 days	Ref		Ref
	Immx 31–90 days before CTx	1.166 (0.762–1.784)	0.478	1.151 (0.731–1.812)	0.544
	Immx 91–180 days before CTX	0.984 (0.638–1.516)	0.941	0.952 (0.595–1.523)	0.838
C: Chemoradiation plus immunotherapy sample (n = 226)
CTx plus immunotherapy	CTx and immx within 30 days	Ref		Ref
	Immx 31–90 days before CTx	0.969 (0.455–2.065)	0.936	0.860 (0.360–2.053)	0.734
	Immx 91–180 days before CTX	0.561 (0.228–1.377)	0.207	0.549 (0.165–1.826)	0.328

CTx, chemotherapy; Immx, immunotherapy; RTx, radiation therapy; Ref, reference.