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. 2020 Sep 2;10:1713. doi: 10.3389/fonc.2020.01713

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Copyright © 2020 Dong, Cao, Luo, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DSCR8 promoted ovarian cancer (OC) progression in vitro. (A) RT-PCR was adopted to test DSCR8 expressions in human normal ovarian epithelial cell line IOSE80 and human OC cell lines A2780, COV644, OV-90, OVCAR-3, As2O3, and SKOV3. ***P < 0.001 compared with the IOSE80 group. (B) DSCR8 overexpressing and knocking down cell models were respectively constructed in A2780 and SKOV-3 cells. (C,D) Cell proliferation was tested by Cell Counting Kit (CCK)8 assay (C) and colony formation assay (D). *P < 0.05, **P < 0.01 vs. NC or sh-NC group, respectively. (E) Apoptosis-related proteins (Bax, Bcl2, and Caspase3) expressions were tested by western blot. (F) Transwell was used for detecting OC cell invasion. (G) Western blot was used to detect epithelial–mesenchymal transition (EMT) markers (E-cadherin, N-cadherin, and Vimentin) expression. *P < 0.05, **P < 0.01, ***P < 0.001.