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. 2020 Sep 2;8:848. doi: 10.3389/fcell.2020.00848

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Copyright © 2020 Thévenod, Lee and Garrick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model of DMT1 participating in mitochondrial iron homeostasis. Keys: DMT1, mitoferrins (Mfrn), ferrous iron (Fe²⁺), Mn²⁺, iron-sulfur cluster proteins (Fe-S-Protein), protoporphyrin IX (PPIX), and heme. Fe²⁺ enters the OMM via DMT1 and an as-yet unidentified pathway (?); while Mn²⁺ apparently relies primarily on DMT1 for import. After entry, the two cations could enter the IMS then pass through Mfrn (lower right) or move directly through Mfrn (lower left). Adapted and redrawn with permission from Garrick and Thévenod (2019).