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. 2020 Sep 2;8:848. doi: 10.3389/fcell.2020.00848

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Copyright © 2020 Thévenod, Lee and Garrick.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Uptake pathways for Fe (A) and Cd (B) via channels, solute carriers (SLCs) and receptors in renal epithelial cells. See text and (Thévenod and Wolff, 2016; Thévenod et al., 2019; Van Swelm et al., 2020) for further details. b0,+AT, amino acid/cystine transporter (SLC7A9/SLC3A1); CatSper, cation channel of sperm; Cav3.1, voltage-gated calcium channel alpha subunit 3.1; DMT1, divalent metal transporter 1 (SLC11A2); MCU, mitochondrial calcium uniporter; megalin:cubilin, the megalin:cubilin:amnionless complex; Mfrn2, mitoferrin 2 (SLC25A28); OCT2, organic cation transporter 2 (SLC22A2); SLC22A17, NGAL/lipocalin 2 receptor; Fe-Tf, holo-transferrin; TfR1, Tf receptor 1; TRPA1, transient receptor potential cation channel subfamily A member 1; TRPML1, transient receptor potential cation channel subfamily ML member 1; TRPV5/6, transient receptor potential cation channel subfamily V members 5/6; ZIP8/14, zinc transporters 8/14 precursors (SLC39A8/A14).