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. 2020 Sep 2;11:2122. doi: 10.3389/fimmu.2020.02122

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Copyright © 2020 Laabei, Colineau, Bettoni, Maziarz, Ermert, Riesbeck, Ram and Blom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FH 6-7/IgG and C4BP1-2/IgM bind to M. catarrhalis. (A,B) Schematic representation of fusion proteins FH6-7/IgG and C4BP1-2/IgM, respectively. (C) Binding of FH6-7/IgG and (D) C4BP1-2/IgM to M. catarrhalis RH4 [wild-type (WT) reference strain] assessed by flow cytometry. (E–H) Binding of RH4 WT and isogenic mutants lacking uspA1 and/or uspA2 to (E) FH6-7/IgG, (F) C4BP1-2/IgM, (G) factor H (FH), and (F) C4b-binding protein (C4BP). Mean (±SD) from three independent experiments are shown. Statistical significance of differences was calculated using one-way ANOVA with Dunnett’s post-test (E–H); **p < 0.01 and ****p < 0.0001.