FIG 1.

Neutralization by TNP of 125 HIV Env-pseudoviruses across major circulating clades. (A) Neutralization potency (IC₅₀/IC₈₀) expressed in micrograms per milliliter and neutralization breadths (expressed as percentages) of VRC01 and VRC03 against different HIV Env-pseudoviruses, as tested using the TZM-bl assays. (B) Neutralization potency (IC₈₀) expressed as micrograms per milliliter of TNP against different HIV Env-pseudoviruses, as tested using the TZM-bl assays. A* includes subtypes A, A(T/F), AC, and ACD. B* includes subtypes B, B(T/F), and BC. C* includes subtypes C and C(T/F). CRF01* includes CRF01_AE and CRF01_AE(T/F). HIV Env-pseudoviruses shaded yellow were used in the experiment for which results are shown in panel A. (C) (Left) Summary of neutralization potencies (IC₈₀) for TNP against the multisubtype pseudoviruses included in panel B. Horizontal bars represent geomean IC₈₀ values. (Right) Arithmetic (x̅), geometric mean, and median TNP IC₈₀ for each subtype. (D) Results of the Games-Howell post hoc test after Welch's one-way analysis of variance. For each pair of means, a plus sign indicates a significant difference (P < 0.05).